Molecular dynamics and thermodynamic integration studies of EGFR kinase mutants suggest a shift in equilibrium between inactive and active states and a difference in binding affinity for Gefitinib

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作者：
Staude, Mike W.
Elcock, Adrian
Zhu, Shun
机构：
[1] Univ No Iowa, Dept Chem & Biochem, Cedar Falls, IA 50614 USA
[2] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 241卷
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
388-CHED
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页数：1
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