Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT

Introduction [Ga-68]PSMA-HBED-CC and [F-18]DCFPyL show a high potential for the detection of recurrent prostate cancer. While F-18-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [F-18]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68 Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal. Methods A comparison of average bone SUV was performed in 17 bone-negative and 4 bone-positive patients. All patients underwent PET/CT 125 minutes after application of [F-18]DCFPyL and 73 minutes after application of [Ga-68]PSMA-HBED-CC at another date. Results Native SUVs in unaffected bone tissue and SUVs relative to liver uptake were lower in [F-18] DCFPyL (0.49) than in [Ga-68]PSMA-HBED-CC scans (0.52). SUVs relative to gluteal muscles did not differ between the two tracers. Average lesional SUVs did not differ between tracers. Conclusion No difference of average bone signal intensity was observed for [F-18]DCFPyL-PET/CT in comparison to [Ga-68]PSMA-HBED-CC scans indicating that diagnostic assessment of the skeleton is not affected by non-specific accumulation of free [F-18]fluoride or 68 Ga.