Kinetic Resolution of β-Lactams via Enantioselective N-Acylation

被引：31

作者：

Yang, Xing ^{[1
]}

Bumbu, Valentina D. ^{[1
]}

Birman, Vladimir B. ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 18期

基金：

美国国家科学基金会;

关键词：

ACYL TRANSFER; NONENZYMATIC ACYLATION; AMINO-ACIDS; BINDING APPROACH; ALCOHOLS; CATALYST; BENZOTETRAMISOLE; DERIVATIVES;

D O I：

10.1021/ol201911z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective N-acylation of 4-aryl-beta-lactams in the presence of acyl transfer catalyst CI-PIQ provides an effective method for their nonenzymatic kinetic resolution.

引用

页码：4755 / 4757

页数：3

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