Synthesis and herbicidal activity of N-(4,6-disubstituted pyrimidin-2-yl)-N′-[1-(heteroaryl)methyl-5-methyl-1H-1,2,3-triazol-4-ylcarbonyl]thiourea

In order to find novel low toxicity and potent herbicides, ten title compounds were synthesized by the multi-step reaction using 2-chloro-5-(chloromethyl)pyridine or 2-chloro-5-(chloromethyl)thiazole as starting materials. The structures of the target compounds were characterized by IR, H-1 NMR, MS spectra and elemental analysis. Preliminary bioassays show that some of the target compounds possess good herbicidal activities against selected weeds at a concentration of 100 mg/L.