In vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes

被引：34

作者：

Gok, Yetkin ^{[1
]}

Akkoc, Senem ^{[2
]}

Erdogan, Hulya ^{[1
]}

Albayrak, Sevil ^{[3
]}

机构：

[1] Inonu Univ, Fac Arts & Sci, Dept Chem, Malatya, Turkey

[2] Erciyes Univ, Dept Chem, TR-38039 Kayseri, Turkey

[3] Erciyes Univ, Dept Biol, TR-38039 Kayseri, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷 / 06期

关键词：

Antimicrobial activity; benzimidazolium salt; N-heterocyclic carbene; silver complex; BENZENE SULFONAMIDES; DERIVATIVES; ANTICANCER; BENZOTHIAZOLE; BENZOXAZOLE; PHENYL; HECK; QSAR;

D O I：

10.3109/14756366.2015.1132210

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of new benzimidazolium salts (1a-g) were synthesized from the reaction of 1-(4-vinylbenzyl) benzimidazole with various alkyl halides. These salts were used to synthesize silver N-heterocyclic carbene (Ag-NHC) complexes (2a-f). The thirteen compounds were characterized by FT-IR, NMR (H-1 and C-13) spectroscopic methods and an elemental analysis technique. These selected candidates were tested for their in vitro antimicrobial activities. Antibacterial and antifungal results indicated that the new salts, and particularly their silver complexes, were found to be strongly effective against seven Gram (-) bacterial strains, three Gram (+) bacterial strains and one yeast (Candida albicans).

引用

页码：1322 / 1327

页数：6

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