Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment

被引：8

作者：

Samuels, Mark ^{[1
]}

Cilibrasi, Chiara ^{[1
]}

Papanastasopoulos, Panagiotis ^{[1
]}

Giamas, Georgios ^{[1
]}

机构：

[1] Univ Sussex, Sch Life Sci, Dept Biochem & Biomed, Brighton BN1 9QG, E Sussex, England

来源：

BIOMOLECULES | 2022年 / 12卷 / 01期

关键词：

breast cancer; therapy resistance; tumour microenvironment; extracellular vesicles; TUMOR-ASSOCIATED MACROPHAGES; MESENCHYMAL STEM-CELLS; NEOADJUVANT CHEMOTHERAPY; PROMOTE MIGRATION; SIGNALING PATHWAY; SUPPRESSOR-CELLS; DENDRITIC CELLS; ESCRT-III; IN-VITRO; EXOSOMES;

D O I：

10.3390/biom12010132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment.

引用

页数：40

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