Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis

被引：22

作者：

Lee, Eunjin ^{[1
]}

Oh, Ji Eun ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol KAIST, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea

[2] Korea Adv Inst Sci & Technol, BioMed Res Ctr, Daejeon 34141, South Korea

来源：

MOLECULES AND CELLS | 2021年 / 44卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

COVID-19; humoral immunity; neutralizing antibody; SARS-CoV-2; variants; NEUTRALIZING ANTIBODIES; MUTATIONS; SPIKE; PERSISTENCE; INFECTION; EMERGENCE; LINEAGE; BINDING; B.1.1.7;

D O I：

10.14348/molcells.2021.0075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV- 2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, and highlight gaps in the current knowledge.

引用

页码：392 / 400

页数：9

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