IL-6 boosts synaptogenesis STAT!

被引：5

作者：

Faust, Travis E. ^{[1
]}

Schafer, Dorothy P. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Neurobiol, Brudnick Neuropsychiat Res Inst, Med Sch, Worcester, MA 01605 USA

来源：

IMMUNITY | 2021年 / 54卷 / 11期

关键词：

FETAL-BRAIN DEVELOPMENT; SCHIZOPHRENIA; INTERLEUKIN-6;

D O I：

10.1016/j.immuni.2021.10.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.

引用

页码：2444 / 2446

页数：3

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