IL-6 boosts synaptogenesis STAT!

被引：5
|
作者：
Faust, Travis E. [1 ]
Schafer, Dorothy P. [1 ]
机构：
[1] Univ Massachusetts, Dept Neurobiol, Brudnick Neuropsychiat Res Inst, Med Sch, Worcester, MA 01605 USA
来源：
IMMUNITY | 2021年 / 54卷 / 11期
关键词：
FETAL-BRAIN DEVELOPMENT; SCHIZOPHRENIA; INTERLEUKIN-6;
D O I：
10.1016/j.immuni.2021.10.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
引用
收藏
页码：2444 / 2446
页数：3
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