Structural-morphological and biological properties of selenium nanoparticles stabilized by bovine serum albumin

被引:23
|
作者
Valueva, S. V. [1 ]
Borovikova, L. N. [1 ]
Koreneva, V. V. [2 ]
Nazarkina, Ya. I. [1 ]
Kipper, A. I. [1 ]
Kopeikin, V. V. [1 ]
机构
[1] Russian Acad Sci, Inst High Mol Weight Cpds, St Petersburg 196140, Russia
[2] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia
基金
俄罗斯基础研究基金会;
关键词
D O I
10.1134/S0036024407070291
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Nanostructures formed during the reduction of ionic selenium in the selenite-ascorbate redox system in an aqueous solution of bovine serum albumin (BSA) were studied using static and dynamic light scattering and flow birefringence. It was established that this process results in the formation of stable aggregates of selenium nanoparticles that adsorb BSA molecules. It was found that highly-ordered superhigh-molecular-weight spherical nanostructures with high density and unique morphology are formed. Experiments with a cell culture of promyelocytic leukemia HL-60 showed that BSA adsorbed on selenium nanoparticles can inhibit the growth of tumor cells and deactivate free radicals with an efficiency comparable with that of sodium selenite.
引用
收藏
页码:1170 / 1173
页数:4
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