Ionotropic receptors in neuronal-astroglial signalling: What is the role of "excitable" molecules in non-excitable cells

被引:83
作者
Lalo, Ulyana [2 ]
Pankratov, Yuriy [3 ]
Parpura, Vladimir [4 ,5 ]
Verkhratsky, Alexei [1 ]
机构
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
[2] Univ Leicester, Leicester LE1 9HN, Leics, England
[3] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
[4] Univ Alabama Birmingham, Dept Neurobiol, Ctr Glial Biol Med, Civitan Int Res Ctr,Atom Force Microscopy & Nanot, Birmingham, AL USA
[5] Univ Alabama Birmingham, Evelyn F McKnight Brain Inst, Birmingham, AL USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2011年 / 1813卷 / 05期
基金
美国国家科学基金会; 英国生物技术与生命科学研究理事会;
关键词
Astrocyte; Glutamate; ATP; NMDA receptor; P2X purinoceptor; Calcium; Sodium; Synapse; BERGMANN GLIAL-CELLS; ASTROCYTES IN-SITU; CENTRAL-NERVOUS-SYSTEM; EXCITATORY AMINO-ACIDS; ION CHANNEL EXPRESSION; METHYL-D-ASPARTATE; WHITE MATTER GLIA; OLIGODENDROCYTE PRECURSOR CELLS; MOUSE CORTICAL ASTROCYTES; HIPPOCAMPAL ASTROCYTES;
D O I
10.1016/j.bbamcr.2010.09.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Astroglial cells were long considered to serve merely as the structural and metabolic supporting cast and scenery against which the shining neurones perform their illustrious duties. Relatively recent evidence, however, indicates that astrocytes are intimately involved in many of the brain's functions. Astrocytes possess a diverse assortment of ionotropic transmitter receptors, which enable these glial cells to respond to many of the same signals that act on neurones. Ionotropic receptors mediate neurone-driven signals to astroglial cells in various brain areas including neocortex, hippocampus and cerebellum. Activation of ionotropic receptors trigger rapid signalling events in astroglia; these events, represented by local Ca2+ or Na+ signals provide the mechanism for fast neuronal-glial signalling at the synaptic level. Since astrocytes can detect chemical transmitters that are released from neurones and can release their own extracellular signals, gliotransmitters, they are intricately involved in homocellular and heterocellular signalling mechanisms in the nervous system. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:992 / 1002
页数:11
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