New dammarane Triterpenes from the aerial parts of Ibicella lutea grown in Argentina

被引：11
作者：
Simirgiotis, MJ
Jiménez, C
Rodriguez, J
Giordano, OS
Tonn, CE
机构：
[1] Univ A Coruna, Fac Ciencias, Dept Quim Fundamental, La Coruna 15071, Spain
[2] Univ Nacl San Luis, Fac Quim Bioquim & Farm, CONICET, INTEQUI, RA-5700 San Luis, Argentina
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 12期
关键词：
D O I：
10.1021/np030273i
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new dammarane triterpenes have been isolated from the aerial parts of Ibicella lutea, 3-acetyl-24-epi-polacandrin (1) and 1,3-diacetyl-24-epi-polacandrin (2), and were obtained along with the known compounds 20S*,24S*-epoxy-3beta,12beta,25-trihydroxydammarane (3) and apigenin. The structures of compounds I and 2 were deduced by spectroscopic studies and by chemical transformations leading to the preparation of derivatives 4-11. The structure and relative stereochemistry of 1 were verified by single-crystal X-ray analysis. The natural compounds and selected semisynthetic derivatives were evaluated against several tumor cells.
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页码：1586 / 1592
页数：7
相关论文
共 19 条
  • [1] 3-OXO-20S,24R-EPOXY-DAMMARANE-25-ZETA,26-DIOL FROM MANGIFERA-INDICA
    ANJANEYULU, V
    BABU, JS
    KRISHNA, MM
    CONNOLLY, JD
    [J]. PHYTOCHEMISTRY, 1993, 32 (02) : 469 - 471
  • [2] APPENDINO G, 1992, PHYTOCHEMISTRY, V31, P923
  • [3] ARRIAGAGINER FJ, 1992, Z NATURFORSCH C, V47, P508
  • [4] BIOGENETICALLY SIGNIFICANT TRITERPENES IN A SPECIES OF MELIACEAE - CABRALEA-POLYTRICHA A JUSS
    CASCON, SC
    BROWN, KS
    [J]. TETRAHEDRON, 1972, 28 (02) : 315 - &
  • [5] A new antibacterial compound from Ibicella lutea
    Cerdeiras, MP
    Fernández, J
    Soubes, M
    Vero, S
    Ferreira, F
    Moyna, P
    Olano, I
    Vázquez, A
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (03) : 521 - 525
  • [6] Cleogynol, a novel dammarane triterpenoid from Cleome gynandra
    Das, PC
    Patra, A
    Mandal, S
    Mallick, B
    Das, A
    Chatterjee, A
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (04): : 616 - 618
  • [7] Farrugia L. J., 1999, J. Appl. Crystallogr, V32, P837, DOI [DOI 10.1107/S0021889899006020, 10.1107/S0021889899006020]
  • [8] STUDIES ON THE CONSTITUENTS OF AERIAL PART OF NEOALSOMITRA-INTEGRIFOLIOLA .2. DAMMARANE GLYCOSIDES FROM AERIAL PART OF NEOALSOMITRA-INTEGRIFOLIOLA
    FUJITA, S
    KASAI, R
    OHTANI, K
    YAMASAKI, K
    MINGHUA, C
    RUILIN, N
    TANAKA, O
    [J]. PHYTOCHEMISTRY, 1995, 39 (03) : 591 - 602
  • [9] DAMMARANE GLYCOSIDES FROM AERIAL PARTS OF NEOALSOMITRA-INTEGRIFOLIOLA
    FUJITA, S
    KASAI, R
    OHTANI, K
    YAMASAKI, K
    CHIU, MH
    NIE, RL
    TANAKA, O
    [J]. PHYTOCHEMISTRY, 1995, 38 (02) : 465 - 472
  • [10] Kasai R, 2000, CHEM PHARM BULL, V48, P1226
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