A preliminary study of the effects of an extract of Ligularia fischeri leaves on type II collagen-induced arthritis in DBA/1J mice

被引：22

作者：

Choi, Eun Mi ^{[1
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 01期

关键词：

Ligularia fischeri; collagen-induced arthritis; DBA/1J mouse;

D O I：

10.1016/j.fct.2007.08.018

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present study was undertaken to determine whether Ligularia fischeri leaf extract (LF) is efficacious against collagen-induced arthritis (CIA) in mice. DBA/1J mice were immunized with bovine type II collagen and treated with LF (100 and 200 mg/kg) for 49 days. Mice were assessed regularly for signs of arthritis and the levels of rheumatoid factor, anti-type II collagen antibody, cytokines, AST, ALT, and creatinine in serum were also examined after the animals were killed. The arthritis score and paw edema were markedly suppressed in the groups treated with LF. Moreover, levels of rheumatoid factor, anti-type II collagen antibody, tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 in sera were reduced by LF administration. These data suggest that L. fischeri might be effective for the treatment of inflammatory arthritis like human rheumatoid arthritis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：375 / 379

页数：5

共 19 条

[1] INHIBITION OF THE PRODUCTION AND EFFECTS OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN RHEUMATOID-ARTHRITIS [J].

AREND, WP ;

DAYER, JM .

ARTHRITIS AND RHEUMATISM, 1995, 38 (02) :151-160

[2]

BEVILACQUA MP, 1993, ANNU REV IMMUNOL, V11, P767, DOI 10.1146/annurev.iy.11.040193.004003

[3]

Choi O. J., 1991, USAGE CONSTITUENTS M, P621

[4] A MECHANISM FOR THE ANTIINFLAMMATORY EFFECTS OF CORTICOSTEROIDS - THE GLUCOCORTICOID RECEPTOR REGULATES LEUKOCYTE ADHESION TO ENDOTHELIAL-CELLS AND EXPRESSION OF ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 AND INTERCELLULAR-ADHESION MOLECULE-1 [J].

CRONSTEIN, BN ;

KIMMEL, SC ;

LEVIN, RI ;

MARTINIUK, F ;

WEISSMANN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :9991-9995

[5]

DEBENEDETTI F, 1992, CLIN EXP RHEUMATOL, V10, P493

[6] Role of cytokines in rheumatoid arthritis [J].

Feldmann, M ;

Brennan, FM ;

Maini, RN .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :397-440

[7] How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end [J].

Firestein, GS ;

Zvaifler, NJ .

ARTHRITIS AND RHEUMATISM, 2002, 46 (02) :298-308

[8] TYPE-II COLLAGEN AUTOIMMUNITY IN ANIMALS AND PROVOCATIONS LEADING TO ARTHRITIS [J].

HOLMDAHL, R ;

ANDERSSON, M ;

GOLDSCHMIDT, TJ ;

GUSTAFSSON, K ;

JANSSON, L ;

MO, JA .

IMMUNOLOGICAL REVIEWS, 1990, 118 :193-232

[9] Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig [J].

Kremer, JM ;

Westhovens, R ;

Leon, M ;

Di Giorgio, E ;

Alten, R ;

Steinfeld, S ;

Russell, A ;

Dougados, M ;

Emery, P ;

Nuamah, IF ;

Williams, GR ;

Becker, JC ;

Hagerty, DT ;

Moreland, LW .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (20) :1907-1915

[10] The genetic and immunopathological processes underlying collagen-induced arthritis [J].

Luross, JA ;

Williams, NA .

IMMUNOLOGY, 2001, 103 (04) :407-416

← 1 2 →