Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia

被引：16

作者：

Lucena, Flavia Campos ^{[1
]}

Lage, Eura Martins ^{[2
]}

Teixeira, Patricia Goncalves ^{[2
]}

Barbosa, Alexandre Simoes ^{[2
]}

Diniz, Rejane ^{[3
]}

Lwaleed, Bashir ^{[4
]}

Talvani, Andre ^{[5
]}

Alpoim, Patricia Nessralla ^{[1
]}

Perucci, Luiza Oliveira ^{[6
]}

SantAna Dusse, Luci Maria ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Pharm, Dept Clin & Toxicol Anal, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Dept Gynecol & Obstet, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Vet, Dept Epidemiol, Belo Horizonte, MG, Brazil

[4] Univ Soutampton, Dept Urol, Southampton, Hants, England

[5] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Dept Biol Sci, Ouro Preto, Brazil

[6] Univ Fed Ouro Preto, Nucleus Res Biol Sci, Ouro Preto, Brazil

来源：

HYPERTENSION IN PREGNANCY | 2019年 / 38卷 / 01期

关键词：

Preeclampsia; D-dimer; PAI-1; longitudinal study; hypercoagulability; PREDICTIVE-VALUE; COAGULATION; HEMOSTASIS; MARKERS; HYPERTENSION; FIBRINOGEN; GESTATION; VARIABLES; OUTCOMES; SYSTEM;

D O I：

10.1080/10641955.2019.1577435

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation. Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups. Conclusion: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.

引用

页码：58 / 63

页数：6

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