Polymyositis and Dermatomyositis: Pathophysiology

被引：34
作者：
Nagaraju, Kanneboyina [2 ,3 ]
Lundberg, Ingrid E. [1 ]
机构：
[1] Karolinska Inst, Dept Med, Rheumatol Unit, Karolinska Univ Hosp, SE-17176 Stockholm, Sweden
[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA
[3] George Washington Univ, Dept Integrat Syst Biol, Med Ctr, Washington, DC 20010 USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2011年 / 37卷 / 02期
基金：
美国国家卫生研究院; 瑞典研究理事会;
关键词：
Polymyositis; Dermatomyositis; Pathogenesis; Adaptive; Innate and nonimmune pathways; Skeletal muscle cell death; Autophagy and endoplasmic reticulum stress; MHC CLASS-I; IDIOPATHIC INFLAMMATORY MYOPATHIES; MYOSITIS-SPECIFIC AUTOANTIBODIES; ENDOPLASMIC-RETICULUM STRESS; INCLUSION-BODY MYOSITIS; TRANSFER-RNA-SYNTHETASE; INTERCELLULAR-ADHESION MOLECULE-1; INTERFERON-ALPHA TREATMENT; UNFOLDED PROTEIN RESPONSE; SKELETAL-MUSCLE LEADS;
D O I：
10.1016/j.rdc.2011.01.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances have increased the understanding of the pathogenesis of polymyositis and dermatomyositis. Clearly, the pathogenesis is complex, and adaptive (eg, autoimmune) and innate and nonimmune pathways play a role in the disease mechanisms, but the relative contribution may vary between patients and in different phases of the disease. Phenotyping patients using autoantibody profiling has resulted in information on molecular pathways that may be relevant in certain subsets of patients with polymyositis or dermatomyositis, but combining the autoantibody profiles with molecular signatures of innate and nonimmune mechanisms would enhance our ability to classify, diagnose, and treat these disorders more effectively.
引用
收藏
页码：159 / +
页数：14
相关论文
共 83 条
  • [61] Costimulatory markers in muscle of patients with idiopathic inflammatory myopathies and in cultured muscle cells
    Nagaraju, K
    Raben, N
    Villalba, ML
    Danning, C
    Loeffler, LA
    Lee, E
    Tresser, N
    Abati, A
    Fetsch, P
    Plotz, PH
    [J]. CLINICAL IMMUNOLOGY, 1999, 92 (02) : 161 - 169
  • [62] Nyberg P, 2000, J RHEUMATOL, V27, P940
  • [63] Denervation-induced oxidative stress and autophagy signaling in muscle
    O'Leary, Michael F. N.
    Hood, David A.
    [J]. AUTOPHAGY, 2009, 5 (02) : 230 - 231
  • [64] A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy
    Oliveira, ALR
    Thams, S
    Lidman, O
    Piehl, F
    Hökfelt, T
    Kärre, K
    Lindä, H
    Cullheim, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) : 17843 - 17848
  • [65] Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis - Interaction with chemokines and Th1 cytokine-producing cells
    Page, G
    Chevrel, G
    Miossec, P
    [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (01): : 199 - 208
  • [66] USE OF MAGNETIC-RESONANCE-IMAGING AND P-31 MAGNETIC-RESONANCE SPECTROSCOPY TO DETECT AND QUANTIFY MUSCLE DYSFUNCTION IN THE AMYOPATHIC AND MYOPATHIC VARIANTS OF DERMATOMYOSITIS
    PARK, JH
    OLSEN, NJ
    KING, L
    VITAL, T
    BUSE, R
    KARI, S
    HERNANZSCHULMAN, M
    PRICE, RR
    [J]. ARTHRITIS AND RHEUMATISM, 1995, 38 (01): : 68 - 77
  • [67] Regulation of class I MHC expression in skeletal muscle: deleterious effect of aberrant expression on myogenesis
    Pavlath, GK
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2002, 125 (1-2) : 42 - 50
  • [68] RETRACTED: VMA21 Deficiency Causes an Autophagic Myopathy by Compromising V-ATPase Activity and Lysosomal Acidification (Retracted article. See vol. 142, pg. 984, 2010)
    Ramachandran, Nivetha
    Munteanu, Iulia
    Wang, Peixiang
    Aubourg, Pauline
    Rilstone, Jennifer J.
    Israelian, Nyrie
    Naranian, Taline
    Paroutis, Paul
    Guo, Ray
    Ren, Zhi-Ping
    Nishino, Ichizo
    Chabrol, Brigitte
    Pellissier, Jean-Francois
    Minetti, Carlo
    Udd, Bjame
    Fardeau, Michel
    Tailor, Chetankumar S.
    Mahuran, Don J.
    Kissel, John T.
    Kalimo, Hannu
    Levy, Nicolas
    Manolson, Morris F.
    Ackerley, Cameron A.
    Minassian, Berge A.
    [J]. CELL, 2009, 137 (02) : 235 - 246
  • [69] Respiratory and limb muscle weakness induced by tumor necrosis factor-α -: Involvement of muscle myofilaments
    Reid, MB
    Lännergren, J
    Westerblad, H
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (04) : 479 - 484
  • [70] RONNBLOM LE, 1990, J INTERN MED, V227, P207
123456789