Polymyositis and Dermatomyositis: Pathophysiology

被引：34
作者：
Nagaraju, Kanneboyina [2 ,3 ]
Lundberg, Ingrid E. [1 ]
机构：
[1] Karolinska Inst, Dept Med, Rheumatol Unit, Karolinska Univ Hosp, SE-17176 Stockholm, Sweden
[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA
[3] George Washington Univ, Dept Integrat Syst Biol, Med Ctr, Washington, DC 20010 USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2011年 / 37卷 / 02期
基金：
美国国家卫生研究院; 瑞典研究理事会;
关键词：
Polymyositis; Dermatomyositis; Pathogenesis; Adaptive; Innate and nonimmune pathways; Skeletal muscle cell death; Autophagy and endoplasmic reticulum stress; MHC CLASS-I; IDIOPATHIC INFLAMMATORY MYOPATHIES; MYOSITIS-SPECIFIC AUTOANTIBODIES; ENDOPLASMIC-RETICULUM STRESS; INCLUSION-BODY MYOSITIS; TRANSFER-RNA-SYNTHETASE; INTERCELLULAR-ADHESION MOLECULE-1; INTERFERON-ALPHA TREATMENT; UNFOLDED PROTEIN RESPONSE; SKELETAL-MUSCLE LEADS;
D O I：
10.1016/j.rdc.2011.01.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances have increased the understanding of the pathogenesis of polymyositis and dermatomyositis. Clearly, the pathogenesis is complex, and adaptive (eg, autoimmune) and innate and nonimmune pathways play a role in the disease mechanisms, but the relative contribution may vary between patients and in different phases of the disease. Phenotyping patients using autoantibody profiling has resulted in information on molecular pathways that may be relevant in certain subsets of patients with polymyositis or dermatomyositis, but combining the autoantibody profiles with molecular signatures of innate and nonimmune mechanisms would enhance our ability to classify, diagnose, and treat these disorders more effectively.
引用
收藏
页码：159 / +
页数：14
相关论文
共 83 条
  • [1] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Appay, V
    Dunbar, PR
    Callan, M
    Klenerman, P
    Gillespie, GMA
    Papagno, L
    Ogg, GS
    King, A
    Lechner, F
    Spina, CA
    Little, S
    Havlir, DV
    Richman, DD
    Gruener, N
    Pape, G
    Waters, A
    Easterbrook, P
    Salio, M
    Cerundolo, V
    McMichael, AJ
    Rowland-Jones, SL
    [J]. NATURE MEDICINE, 2002, 8 (04) : 379 - 385
  • [2] MONOCLONAL-ANTIBODY ANALYSIS OF MONONUCLEAR-CELLS IN MYOPATHIES .1. QUANTITATION OF SUBSETS ACCORDING TO DIAGNOSIS AND SITES OF ACCUMULATION AND DEMONSTRATION AND COUNTS OF MUSCLE-FIBERS INVADED BY T-CELLS
    ARAHATA, K
    ENGEL, AG
    [J]. ANNALS OF NEUROLOGY, 1984, 16 (02) : 193 - 208
  • [3] An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity
    Baechler, Emily C.
    Bauer, Jason W.
    Slattery, Catherine A.
    Ortmann, Ward A.
    Espe, Karl J.
    Novitzke, Jill
    Ytterberg, Steven R.
    Gregersen, Peter K.
    Behrens, Timothy W.
    Reed, Ann M.
    [J]. MOLECULAR MEDICINE, 2007, 13 (1-2) : 59 - 68
  • [4] BARTOCCIONI E, 1994, CLIN EXP IMMUNOL, V95, P166
  • [5] A local antigen-driven humoral response is present in the inflammatory myopathies
    Bradshaw, Elizabeth M.
    Orihuela, Ana
    McArdel, Shannon L.
    Salajegheh, Mohammad
    Amato, Anthony A.
    Hafler, David A.
    Greenberg, Steven A.
    O'Connor, Kevin C.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (01) : 547 - 556
  • [6] Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    Casciola-Rosen, L
    Nagaraju, K
    Plotz, P
    Wang, K
    Levine, S
    Gabrielson, E
    Corse, A
    Rosen, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (04) : 591 - 601
  • [7] Contribution of tumour necrosis factor α and interleukin (IL) 1β to IL6 production, NF-κB nuclear translocation, and class I MHC expression in muscle cells:: in vitro regulation with specific cytokine inhibitors
    Chevrel, G
    Granet, C
    Miossec, P
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (09) : 1257 - 1262
  • [8] The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis
    Chinoy, Hector
    Fertig, Noreen
    Oddis, Chester V.
    Ollier, William E. R.
    Cooper, Robert G.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (10) : 1345 - 1349
  • [9] Polymyositis and dermatomyositis
    Dalakas, MC
    Hohlfeld, R
    [J]. LANCET, 2003, 362 (9388) : 971 - 982
  • [10] Role of cytokines and chemokines in idiopathic inflammatory myopathies
    De Paepe, Boel
    Creus, Kim K.
    De Bleecker, Jan L.
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2009, 21 (06) : 610 - 616
123456789