Specific extraction of nucleic acids employing pillar[6]arene-functionalized nanochannel platforms

被引：3
|
作者：
Li, Yu [1 ,2 ]
Li, Wenjie [2 ]
Xu, Weiwei [2 ]
Huang, Jinmei [2 ]
Sun, Zhongyue [3 ]
Liao, Tangbin [4 ]
Kovaleva, Elena G. [5 ]
Xu, Chuanlai [1 ]
Cheng, Jing [1 ,2 ]
Li, Haibing [1 ,2 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China
[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China
[3] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China
[4] Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China
[5] Ural Fed Univ, Dept Technol Organ Synth, Mira St 28, Ekaterinburg 620002, Russia
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 66期
基金：
中国国家自然科学基金;
关键词：
TRANSPORT;
D O I：
10.1039/d2cc02693g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The rapid extraction of high-purity nucleic acids from complex biological samples using conventional methods is complicated. Therefore, in this study, glycine-pillar[6]arene (Gly-P6)-functionalized tapered nanochannels were constructed using 32-mer single-stranded E. coli DNA (ssDNA) as a model sequence, which can selectively transport ssDNA by multiple noncovalent forces (transport flux of 2.65 nM cm(-2) h(-1)) under the interference of amino acids and other substances. In view of these prospective results, the selective transport of nucleic acids with nanochannels could be applied in the design of nucleic acid enrichment and separation systems in the future.
引用
收藏
页码：9278 / 9281
页数：4
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