Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis

被引：6

作者：

Roiz-Santianez, Roberto ^{[1
]}

Crespo-Facorro, Benedicto ^{[1
]}

Perez-Iglesias, Rocio ^{[1
]}

Pelayo-Teran, Jose Maria ^{[1
]}

Carrasco-Marin, Eugenio ^{[2
]}

Mata, Ignacio ^{[1
]}

Sanchez, Elena ^{[3
]}

Leyva-Cobian, Francisco ^{[2
]}

Vazquez-Barquero, Jose Luis ^{[1
]}

机构：

[1] Univ Cantabria, Univ Hosp Marques Valdecilla, Sch Med, Dept Psychiat, Santander 39008, Spain

[2] Univ Hosp Marques Valdecilla, Dept Immunol, Santander, Spain

[3] Univ Hosp Marques Valdecilla, Dept Neuroradiol, Santander, Spain

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2008年 / 162卷 / 02期

关键词：

structural neuroimaging; MRI; brain morphometry; schizophrenia; gene; interleukin-1 receptor antagonist genotype;

D O I：

10.1016/j.pscychresns.2007.10.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1 RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1 RN gene and brain morphometry at early phases of the illness. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：167 / 171

页数：5

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