Relevance of molecular weight of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride and their antioxidant activities

被引：39

作者：

Xing, Ronge ^{[1
]}

Liu, Song ^{[1
]}

Guo, Zhanyong ^{[1
,2
]}

Yu, Huahua ^{[1
]}

Zhong, Zhimei ^{[1
,2
]}

Ji, Xia ^{[1
,2
]}

Li, Pengcheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 02期

关键词：

high molecular weight chitosan-N-2-hydroxypropyl trimethyl ammonium chloride; low molecular weight chitosan-N-2-hydroxypropyl trimethyl; ammonium chloride; radical scavenging effect; reducing power; chelating effect; comparative relevance;

D O I：

10.1016/j.ejmech.2007.03.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antioxidant potency of high/low molecular weight quatemary chitosan derivatives was investigated employing various established systems in vitro, such as superoxide (O-2(center dot-)) and hydroxyl (center dot OH) radicals scavenging, reducing power and iron ion chelating. As expected, we obtained several satisfying results, as follow: firstly, low molecular weight quaternary chitosan had stronger scavenging effect on O-2(center dot-) and center dot OH than high molecular weight quaternary chitosan. Secondly, the reducing power of low molecular weight quaternary chitosan was more pronounced than that of high molecular weight quaternary chitosan. Thirdly, ferrous ion chelating potency were showed to increase first and decrease afterwards with increasing concentration for two kinds of quaternary chitosans, namely, they have not concentration-dependence. However, the scavenging rate and reducing power of high and low molecular weight quaternary chitosans increased with their increasing conc centrations, and hence were concentration-dependent. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：336 / 340

页数：5

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