Pharmacological properties of some aminoalkanolic derivatives of xanthone

被引：0
|
作者：
Marona, H [1 ]
Pekala, E
Filipek, B
Maciag, D
Szneler, E
机构：
[1] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Chem Technol Drugs, PL-30688 Krakow, Poland
[2] Jagiellonian Univ, Coll Med, Fac Pharm, Lab Pharmacol Screening, PL-30688 Krakow, Poland
[3] Jagiellonian Univ, Fac Chem, PL-30688 Krakow, Poland
来源：
PHARMAZIE | 2001年 / 56卷 / 07期
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D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of appropriate aminoisopropanoloxy derivatives of 2-, 3- or 6-xanthone was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). The most interesting result was the anticonvulsant activity of (+/-)-3-(2-propylamino)-1-[(2-methyl)-6-xanthonoxy]-2-propanol hydrochloride (10), which displayed anti-MES activity with a protective index (TD50/ED50) of 0.80. Some of the obtained compounds were also tested for their effect on the circulatory system (influence on the non-working heart perfusion, protection against adrenaline induced-arrhythmia) and acute toxicity.
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页码：567 / 572
页数：6
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