Mechanisms of Musculoskeletal Frailty in People Living with HIV

被引：0

作者：

Nelson, Amy K. ^{[1
,5
,6
]}

Fiskum, G. ^{[2
]}

Renn, C. ^{[3
]}

Zhu, S. ^{[4
]}

Kottilil, S. ^{[5
]}

Klinedinst, N. J. ^{[4
]}

机构：

[1] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Anesthesiol, Baltimore, MD 21201 USA

[3] Univ Maryland, Pain & Translat Symptom Sci, Sch Nursing, Baltimore, MD 21201 USA

[4] Univ Maryland, Dept Org Syst & Adult Hlth, Sch Nursing, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[6] 725 W Lombard St N143, Baltimore, MD 21201 USA

来源：

JOURNAL OF FRAILTY & AGING | 2022年 / 11卷 / 01期

关键词：

Mitochondria; inflammation; immune activation; endocrine alterations; aerobic exercise; PHYSICAL-ACTIVITY; ANTIRETROVIRAL-THERAPY; OLDER-ADULTS; MITOCHONDRIAL RESPIRATION; MUSCLE MITOCHONDRIA; IMMUNE ACTIVATION; POSITIVE PATIENTS; AEROBIC EXERCISE; OXIDATIVE STRESS; INFLAMMATION;

D O I：

10.14283/jfa.2021.44

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

People over age 50 living with HIV experience frailty including functional declines and illnesses usually attributed to aging, more frequently and ten years earlier than people without HIV. As the number of people living with HIV over age 50 is expected to triple by the year 2040, those experiencing early frailty will continue to grow. This review synthesizes the known correlates and contributors to musculoskeletal frailty in people living with HIV. A conceptual model of musculoskeletal frailty in HIV that outlines chronic inflammation, altered energy metabolism, immune activation, and endocrine alterations as mechanisms associated with frailty development is presented. Additionally, the potential ability of aerobic exercise to modify the risk of frailty is highlighted as an important intervention.

引用

页码：83 / 90

页数：8

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