Significant role of cationic polymers in drug delivery systems

被引：75
|
作者：
Farshbaf, Masoud [1 ]
Davaran, Soodabeh [2 ]
Zarebkohan, Amir [1 ]
Annabi, Nasim [3 ,4 ,5 ]
Akbarzadeh, Abolfazl [1 ]
Salehi, Roya [6 ,7 ]
机构：
[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran
[2] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[3] Harvard Med Sch, Brigham & Womens Hosp, Biomat Innovat Res Ctr, Cambridge, MA USA
[4] MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA
[5] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
[6] Tabriz Univ Med Sci, Fac Adv Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[7] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2018年 / 46卷 / 08期
关键词：
Cationic polymers; nanoparticles; drug delivery; biodegradable; drug loading; IN-VITRO; CHITOSAN NANOPARTICLES; GELATIN NANOPARTICLES; BREAST-CANCER; L-LYSINE; TARGETED DELIVERY; SURFACE MODIFICATION; POLY(AMIDO AMINE)S; GLYCOL CHITOSAN; GRAPHENE OXIDE;
D O I：
10.1080/21691401.2017.1395344
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cationic polymers are characterized as the macromolecules that possess positive charges, which can be either inherently in the polymer side chains and/or its backbone. Based on their origins, cationic polymers are divided in two category including natural and synthetic, in which the possessed positive charges are as result of primary, secondary or tertiary amine functional groups that could be protonated in particular situations. Cationic polymers have been employed commonly as drug delivery agents due to their superior encapsulation efficacy, enhanced bioavailability, low toxicity and improved release profile. In this paper, we focus on the most prominent examples of cationic polymers which have been revealed to be applicable in drug delivery systems and we also discuss their general synthesis and surface modification methods as well as their controlled release profile in drug delivery.
引用
收藏
页码：1872 / 1891
页数：20
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