Indazolones Directed Rh(III)-Catalyzed C-H Amidation of Arenes

被引：5

作者：

Chen, Shao-Yong ^{[1
,2
,3
]}

Zheng, Yi-Chuan ^{[3
]}

Liu, Xu-Ge ^{[4
]}

Song, Jia-Lin ^{[3
]}

Shu, Bing ^{[3
]}

Zheng, Tao ^{[3
]}

Xiao, Lin ^{[3
]}

Zhang, Shang-Shi ^{[3
]}

Cao, Hua ^{[1
,2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China

[2] Guangdong Pharmaceut Univ, Guangdong Cosmet Engn & Technol Res Ctr, Zhongshan 528458, Peoples R China

[3] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China

[4] Henan Univ, Sch Pharm, Kaifeng 475004, Henan, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 18期

关键词：

Indazolones; Rh(III)-Catalyzed; C-H activation; Amidation; ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; CINNOLINES; RECEPTOR;

D O I：

10.1002/adsc.202200570

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The Cp*Rh(III)-catalyzed indazolone-directed C-H bond amidation of arenes has been realized by employing sulfonyl azide agents and dioxazolones as nitrogen source. This protocol displays mild conditions, broad substrate scope and high functional group compatibility. What' more, the late-stage modifications of structure complicated drugs, such as Gemfibrozil, Oxaprozin, Probenecid and Naproxen, has been demonstrated. Furthermore, preliminary mechanistic investigation and an exploratory reaction mechanism were also proposed.

引用

页码：3302 / 3309

页数：8

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