Biased excitable networks: how cells direct motion in response to gradients

被引：101
作者：
Iglesias, Pablo A. [1 ]
Devreotes, Peter N. [2 ]
机构：
[1] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA
[2] Johns Hopkins Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 02期
基金：
美国国家卫生研究院;
关键词：
REACTION-DIFFUSION WAVES; PSEUDOPODIUM EXTENSION; EUKARYOTIC CHEMOTAXIS; ACTIN; LOCOMOTION; MODELS; OSCILLATIONS; ORGANIZATION; ACTIVATION; MOTILITY;
D O I：
10.1016/j.ceb.2011.11.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The actin cytoskeleton in motile cells has many of the hallmarks of an excitable medium, including the presence of propagating waves. This excitable behavior can account for the spontaneous migration of cells. A number of reports have suggested that the chemoattractant-mediated signaling can bias excitability, thus providing a means by which cell motility can be directed. In this review, we discuss some of these observations and theories proposed to explain them. We also suggest a mechanism for cell polarity that can be incorporated into the existing framework.
引用
收藏
页码：245 / 253
页数：9
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