Detection of DNA Methylation Changes in Body Fluids

被引：0

作者：

Liloglou, Triantafillos ^{[1
]}

Field, John K. ^{[1
]}

机构：

[1] Univ Liverpool, Canc Res Ctr, Liverpool L69 3BX, Merseyside, England

来源：

EPIGENETICS AND CANCER, PT B | 2010年 / 71卷

关键词：

GENE PROMOTER HYPERMETHYLATION; TUMOR-SPECIFIC METHYLATION; CPG ISLAND METHYLATION; PURE PANCREATIC-JUICE; LUNG-CANCER PATIENTS; ABERRANT METHYLATION; MULTIPLE GENES; PLASMA DNA; SERUM DNA; HIGH-RISK;

D O I：

10.1016/S0065-2660(10)71006-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation deregulation is one of the major components of epigenetic reprogramming affecting many human diseases. Due to its chemical nature and the advances in technology, DNA methylation is unique for biomarker utilization. DNA methylation changes have been detected in a variety of human body fluids associated with a large number of malignant and benign diseases. This chapter summarizes the evidence from a wide range of studies in this field and demonstrates the clinical potential of DNA methylation in cancer diagnostics. The technical approaches are discussed, emphasizing on quality control issues and potential pitfalls. Finally, the lack of transferring this technology to the clinic is being discussed, highlighting key study design issues that are required for biomarker validation and clinical implementation. (C) 2010, Elsevier Inc.

引用

页码：177 / 207

页数：31

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