Cancer and the bromodomains of BAF180

被引：23

作者：

Brownlee, Peter M. ^{[1
]}

Chambers, Anna L. ^{[1
]}

Oliver, Antony W. ^{[2
]}

Downs, Jessica A. ^{[1
]}

机构：

[1] Univ Sussex, MRC Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] Univ Sussex, Genome Damage & Stabil Ctr, Canc Res UK DNA Repair Enzymes Res Grp, Brighton BN1 9RQ, E Sussex, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

关键词：

BAF180; bromodomain; cancer; chromatin remodelling complex; polybromo/Brg1-associated factor (PBAF); Snf2; superfamily; CHROMATIN-REMODELING COMPLEX; SWI/SNF; ACETYLATION; RSC; SPECIFICITY; GAMMA-H2AX; EXPRESSION; INDUCTION; SUBUNIT; H3;

D O I：

10.1042/BST20110754

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

引用

页码：364 / 369

页数：6

共 28 条

[1] Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence [J].

Burrows, Anna E. ;

Smogorzewska, Agata ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (32) :14280-14285

[2] Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains [J].

Cairns, BR ;

Schlichter, A ;

Erdjument-Bromage, H ;

Tempst, P ;

Kornberg, RD ;

Winston, F .

MOLECULAR CELL, 1999, 4 (05) :715-723

[3] Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions [J].

Chandrasekaran, Renu ;

Thompson, Martin .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 355 (03) :661-666

[4] Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress [J].

Charles, Georgette M. ;

Chen, Changbin ;

Shih, Susan C. ;

Collins, Sean R. ;

Beltrao, Pedro ;

Zhang, Xin ;

Sharma, Tanu ;

Tan, Song ;

Burlingame, Alma L. ;

Krogan, Nevan J. ;

Madhani, Hiten D. ;

Narlikar, Geeta J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (26) :10620-10625

[5] Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2 [J].

Charlop-Powers, Zachary ;

Zeng, Lei ;

Zhang, Qiang ;

Zhou, Ming-Ming .

CELL RESEARCH, 2010, 20 (05) :529-538

[6] The Biology of Chromatin Remodeling Complexes [J].

Clapier, Cedric R. ;

Cairns, Bradley R. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 :273-304

[7]

DeCristofaro MF, 2001, J CELL PHYSIOL, V186, P136

[8] Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180 [J].

Huang, Xuling ;

Gao, Xiaolin ;

Diaz-Trelles, Ramon ;

Ruiz-Lozano, Pilar ;

Wang, Zhong .

DEVELOPMENTAL BIOLOGY, 2008, 319 (02) :258-266

[9] Protein structure prediction on the Web: a case study using the Phyre server [J].

Kelley, Lawrence A. ;

Sternberg, Michael J. E. .

NATURE PROTOCOLS, 2009, 4 (03) :363-371

[10] A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair [J].

Lee, Han-Sae ;

Park, Ji-Hye ;

Kim, So-Jung ;

Kwon, Su-Jung ;

Kwon, Jongbum .

EMBO JOURNAL, 2010, 29 (08) :1434-1445

← 1 2 3 →