Cancer and the bromodomains of BAF180

被引：23
作者：
Brownlee, Peter M. [1 ]
Chambers, Anna L. [1 ]
Oliver, Antony W. [2 ]
Downs, Jessica A. [1 ]
机构：
[1] Univ Sussex, MRC Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
[2] Univ Sussex, Genome Damage & Stabil Ctr, Canc Res UK DNA Repair Enzymes Res Grp, Brighton BN1 9RQ, E Sussex, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷
关键词：
BAF180; bromodomain; cancer; chromatin remodelling complex; polybromo/Brg1-associated factor (PBAF); Snf2; superfamily; CHROMATIN-REMODELING COMPLEX; SWI/SNF; ACETYLATION; RSC; SPECIFICITY; GAMMA-H2AX; EXPRESSION; INDUCTION; SUBUNIT; H3;
D O I：
10.1042/BST20110754
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.
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收藏
页码：364 / 369
页数：6
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