Synthetic studies towards ML-3000 - A concise synthesis of this non-steroidal anti-inflammatory drug

被引：11

作者：

Cossy, J ^{[1
]}

Belotti, D ^{[1
]}

机构：

[1] Ecole Super Phys & Chim Ind, CNRS, Chim Organ Lab, F-75231 Paris 05, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(99)00176-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

ML-3000 was obtained from 1-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an omega-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5145 / 5156

页数：12

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