Synthetic studies towards ML-3000 - A concise synthesis of this non-steroidal anti-inflammatory drug

被引：11
作者：
Cossy, J [1 ]
Belotti, D [1 ]
机构：
[1] Ecole Super Phys & Chim Ind, CNRS, Chim Organ Lab, F-75231 Paris 05, France
来源：
TETRAHEDRON | 1999年 / 55卷 / 16期
关键词：
D O I：
10.1016/S0040-4020(99)00176-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
ML-3000 was obtained from 1-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an omega-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：5145 / 5156
页数：12
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