HBV, HCV, and HBV/HCV co-infection among HIV-positive patients in Hunan province, China: Regimen selection, hepatotoxicity, and antiretroviral therapy outcome

被引:4
作者
Su, Shu [1 ]
Fairley, Christopher K. [2 ,3 ]
Sasadeusz, Joe [2 ]
He, Jianmei [4 ]
Wei, Xiuqing [4 ]
Zeng, Huan [5 ]
Jing, Jun [6 ]
Mao, Limin [7 ]
Chen, Xi [4 ]
Zhang, Lei [1 ,2 ,3 ,6 ]
机构
[1] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
[2] Alfred Hlth, Melbourne Sexual Hlth Ctr, Melbourne, Vic, Australia
[3] Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Melbourne, Vic, Australia
[4] Hunan Prov Ctr Dis Control & Prevent, Loudi, Hunan, Peoples R China
[5] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China
[6] Tsinghua Univ, Res Ctr Publ Hlth, Beijing, Peoples R China
[7] Univ New South Wales, Fac Arts & Social Sci, Ctr Social Res Hlth, Sydney, NSW, Australia
关键词
antiretroviral drug; hepatitis B virus; hepatitis C virus; human immunodeficiency virus; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; NEW-YORK-CITY; RISK-FACTORS; INFECTED PATIENTS; LIVER FIBROSIS; B-VIRUS; INJECT DRUGS; DISEASE; PREVALENCE;
D O I
10.1002/jmv.24988
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Co-infection with hepatitis B (HBV) and C (HCV) is common among people living with HIV (PLHIV). This study investigates the impacts of hepatitis co-infection on antiretroviral therapy (ART) outcomes and hepatotoxicity in PLHIV. The cohort study included 1984 PLHIV. Hepatotoxicity was defined by elevated alanine aminotransferase (ALT) levels. ART outcomes were measured by CD4 cell counts, viral load, and mortality rate in patients. Among 1984 PLHIV, 184 (9.3%) were co-infected with HBV and 198 (10.0%) with HCV and 54 (2.7%) were co-infected with HBV and HCV. Of these patients, 156 (7.9%) had ALT elevationgrade 1 at baseline. During the course of ART, the mortality rate and its adjusted hazard ratio (AHR) in PLHIV who were co-infected with HCV (2.6/100person-years [py], AHR=2.3, 95%CI 1.1-4.7) was higher than for patients with mono-infected HIV, as it was for those with an elevated ALT (4.4/100 py, AHR=3.8, [1.7-8.2]) at baseline compared to those with normal ALT. After 6-12 months of ART, the incidence of hepatotoxicity among all the patients was 3.7/100 py. The risk of hepatotoxicity was higher in HCV co-infected (18.6/100py, adjusted odds ratio [AOR]=12.4, [8.1-18.2]) than HIV mono-infected patients, and for all regimens (nevirapine: 30.0/100py, 34.2, 7.3-47.9; zidovudine/stavudine: 24.7/100py, 22.1, 7.1-25.5; efavirenz: 14.5/100py, 9.4, 3.5-19.2; lopinavir/ritonavir: 40.1/100py, 52.2, 9.5-88.2) except tenofovir (4.3/100py, 4.9, 0.8-9.5). Patients with HBV/HCV co-infected had high hepatotoxicity (10.0/100py, 6.3, 1.2-23.3) over the same period. Patients with HCV co-infection and HBV/HCV co-infection demonstrated higher hepatotoxicity rate compared with HIV mono-infected patients in China.
引用
收藏
页码:518 / 525
页数:8
相关论文
共 58 条
[41]   HIV and viral hepatitis co-infection in New York City, 2000-2010: prevalence and case characteristics [J].
Prussing, C. ;
Chan, C. ;
Pinchoff, J. ;
Kersanske, L. ;
Bornschlegel, K. ;
Balter, S. ;
Drobnik, A. ;
Fuld, J. .
EPIDEMIOLOGY AND INFECTION, 2015, 143 (07) :1408-1416
[42]   Prevalence and Outcomes of Hepatitis B Coinfection and Associated Liver Disease Among Antiretroviral Therapy-Naive Individuals in a Rural Tanzanian Human Immunodeficiency Virus Cohort [J].
Ramirez-Mena, Adria ;
Glass, Tracy R. ;
Winter, Annja ;
Kimera, Namvua ;
Ntamatungiro, Alex ;
Hatz, Christoph ;
Tanner, Marcel ;
Battegay, Manuel ;
Furrer, Hansjakob ;
Wandeler, Gilles ;
Letang, Emilio .
OPEN FORUM INFECTIOUS DISEASES, 2016, 3 (03)
[43]  
Reust CE, 2011, AM FAM PHYSICIAN, V83, P1443
[44]   Differential predictors of ART adherence among HIV-monoinfected versus HIV/HCV-coinfected individuals [J].
Shuper, Paul A. ;
Joharchi, Narges ;
Irving, Hyacinth ;
Fletcher, David ;
Kovacs, Colin ;
Loutfy, Mona ;
Walmsley, Sharon L. ;
Wong, David K. H. ;
Rehm, Juergen .
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2016, 28 (08) :954-962
[45]   Effect of abacavir on sustained virologic response to HCV treatment in HIV/HCV co-infected patients, Cohere in Eurocoord [J].
Smit, Colette ;
Smit, Colette ;
Arends, Joop ;
Peters, Lars ;
d'Arminio, Antonella ;
Dabis, Montforte Francois ;
Zangerle, Robert ;
Daikos, George ;
Mussini, Christina ;
Mallolas, Josep ;
de Wit, Stephane ;
Zinkernagel, Annelies ;
Cosin, Jaime ;
Chene, Genevieve ;
Raben, Dorthe ;
Rockstroh, Juergen .
BMC INFECTIOUS DISEASES, 2015, 15
[46]   High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, Uganda [J].
Stabinski, Lara ;
Reynolds, Steven J. ;
Ocama, Ponsiano ;
Laeyendecker, Oliver ;
Ndyanabo, Anthony ;
Kiggundu, Valerian ;
Boaz, Iga ;
Gray, Ron H. ;
Wawer, Maria ;
Thio, Chloe ;
Thomas, David L. ;
Quinn, Thomas C. ;
Kirk, Gregory D. .
ANTIVIRAL THERAPY, 2011, 16 (03) :405-411
[47]   Ombitasvir, Paritaprevir Co-dosed With Ritonavir, Dasabuvir, and Ribavirin for Hepatitis C in Patients Co-infected With HIV-1 A Randomized Trial [J].
Sulkowski, Mark S. ;
Eron, Joseph J. ;
Wyles, David ;
Trinh, Roger ;
Lalezari, Jay ;
Wang, Chia ;
Slim, Jihad ;
Bhatti, Laveeza ;
Gathe, Joseph ;
Ruane, Peter J. ;
Elion, Richard ;
Bredeek, Fritz ;
Brennan, Robert ;
Blick, Gary ;
Khatri, Amit ;
Gibbons, Krystal ;
Hu, Yiran B. ;
Fredrick, Linda ;
Schnell, Gretja ;
Pilot-Matias, Tami ;
Tripathi, Rakesh ;
Da Silva-Tillmann, Barbara ;
McGovern, Barbara ;
Campbell, Andrew L. ;
Podsadecki, Thomas .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (12) :1223-1231
[48]   Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: Role of hepatitis C and B infections [J].
Sulkowski, MS ;
Thomas, DL ;
Mehta, SH ;
Chaisson, RE ;
Moore, RD .
HEPATOLOGY, 2002, 35 (01) :182-189
[49]   Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection [J].
Sulkowski, MS ;
Thomas, DL ;
Chaisson, RE ;
Moore, RD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (01) :74-80
[50]   Hepatitis B and C Co-Infection among HIV-Infected Adults while on Antiretroviral Treatment: Long-Term Survival, CD4 Cell Count Recovery and Antiretroviral Toxicity in Cambodia [J].
van Griensven, Johan ;
Phirum, Lay ;
Choun, Kimcheng ;
Sopheak Thai ;
De Weggheleire, Anja ;
Lynen, Lutgarde .
PLOS ONE, 2014, 9 (02)