Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

被引：242

作者：

Nath, Bharath ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

来源：

HEPATOLOGY | 2012年 / 55卷 / 02期

关键词：

OBSTRUCTIVE SLEEP-APNEA; ENDOTHELIAL GROWTH-FACTOR; CHRONIC INTERMITTENT HYPOXIA; VIRUS-X-PROTEIN; HEPATIC STELLATE CELLS; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; RAT-LIVER; NONALCOHOLIC STEATOHEPATITIS; FACTOR; 1-ALPHA;

D O I：

10.1002/hep.25497

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models. (HEPATOLOGY 2012;)

引用

页码：622 / 633

页数：12

共 105 条

[61] Hypoxia-Inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis [J].

Qu, Aijuan ;

Taylor, Matthew ;

Xue, Xiang ;

Matsubara, Tsutomu ;

Metzger, Daniel ;

Chambon, Pierre ;

Gonzalez, Frank J. ;

Shah, Yatrik M. .

HEPATOLOGY, 2011, 54 (02) :472-483

[62] Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism [J].

Rankin, Erinn B. ;

Rha, Jennifer ;

Selak, Mary A. ;

Unger, Travis L. ;

Keith, Brian ;

Liu, Qingdu ;

Haase, Volker H. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (16) :4527-4538

[63] Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice [J].

Redaelli, CA ;

Semela, D ;

Carrick, FE ;

Ledermann, M ;

Candinas, D ;

Sauter, B ;

Dufour, JF .

JOURNAL OF HEPATOLOGY, 2004, 40 (02) :305-312

[64] Hyperbaric oxygen preconditioning promotes angiogenesis in rat liver after partial hepatectomy [J].

Ren, Ping ;

Kang, ZhiMing ;

Gu, GuoJun ;

Liu, Yun ;

Xu, WeiGang ;

Tao, HengYi ;

Zhang, John H. ;

Sun, XueJun ;

Ji, Hui .

LIFE SCIENCES, 2008, 83 (7-8) :236-241

[65] Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation [J].

Ripoli, Maria ;

D'Aprile, Annamaria ;

Quarato, Giovanni ;

Sarasin-Filipowicz, Magdalena ;

Gouttenoire, Jerome ;

Scrima, Rosella ;

Cela, Olga ;

Boffoli, Domenico ;

Heim, Markus H. ;

Moradpour, Darius ;

Capitanio, Nazzareno ;

Piccoli, Claudia .

JOURNAL OF VIROLOGY, 2010, 84 (01) :647-660

[66] NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α [J].

Rius, Jordi ;

Guma, Monica ;

Schachtrup, Christian ;

Akassoglou, Katerina ;

Zinkernagel, Annelies S. ;

Nizet, Victor ;

Johnson, Randall S. ;

Haddad, Gabriel G. ;

Karin, Michael .

NATURE, 2008, 453 (7196) :807-U9

[67] Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes [J].

Roth, U ;

Jungermann, K ;

Kietzmann, T .

BIOLOGICAL CHEMISTRY, 2004, 385 (3-4) :239-247

[68] Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma [J].

Ryu, Soo Hyung ;

Chung, Young-Hwa ;

Lee, Hyunseung ;

Kim, Jeong A. ;

Shin, Hyun Deok ;

Min, Hyun Joo ;

Seo, Dong Dae ;

Jang, Myoung Kuk ;

Yu, Eunsil ;

Kim, Kyu-Won .

HEPATOLOGY, 2008, 47 (03) :929-936

[69] Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1α expression [J].

Salhanick, Steven D. ;

Belikoff, Bryan ;

Orlow, Daniel ;

Holt, Douglas ;

Reenstra, Wende ;

Buras, Jon A. .

ACADEMIC EMERGENCY MEDICINE, 2006, 13 (07) :707-714

[70] Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver [J].

Savransky, Vladimir ;

Bevans, Shannon ;

Nanayakkara, Ashika ;

Li, Jianguo ;

Smith, Philip L. ;

Torbenson, Michael S. ;

Polotsky, Vsevolod Y. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 293 (04) :G871-G877

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