Synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component reaction in poly(ethylene glycol)

被引：66

作者：

Zareai, Zeinab ^{[3
]}

Khoobi, Mehdi ^{[2
]}

Ramazani, Ali ^{[3
]}

Foroumadi, Alireza ^{[2
]}

Souldozi, Ali ^{[4
]}

Slepokura, Katarzyna ^{[5
]}

Lis, Tadeusz ^{[5
]}

Shafiee, Abbas ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14176, Iran

[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14176, Iran

[3] Univ Zanjan, Dept Chem, Zanjan, Iran

[4] Islamic Azad Univ, Urmia Branch, Dept Chem, Orumiyeh, Iran

[5] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

来源：

TETRAHEDRON | 2012年 / 68卷 / 33期

基金：

美国国家科学基金会;

关键词：

Multicomponent reaction; Furo[3,2-c]coumarin; 4-Hydroxycoumarin; Oxidation; X-ray single crystal structure analysis; Poly(ethylene glycol); MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; FACILE SYNTHESIS; CYCLOADDITION; DERIVATIVES; SYSTEM;

D O I：

10.1016/j.tet.2012.05.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward synthesis of functionalized furo[3,2-c]coumarins via a one-pot oxidative pseudo three-component condensation of aldehydes and 4-hydroxycoumarin (2 equiv) in poly(ethylene glycol) (PEG) as solvent is described. A mixture of I-2 and K2S2O8 in the presence of Na2CO3 was used as an oxidative reagent. The structure of the furo[3,2-c]coumarins was established by X-ray single crystal structure analysis. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6721 / 6726

页数：6

共 35 条

[1] Regio and diastereoselective synthesis of functionalized 2,3-dihydrofuro[3,2-c]coumarins via a one-pot three-component reaction [J].