Discovery of potent antimicrobial peptide analogs of Ixosin-B

被引：13

作者：

Lung, Feng-Di T. ^{[1
]}

Wang, Kai-Shiuan ^{[1
]}

Liao, Zih-Jie ^{[1
]}

Hsu, Sheng-Kai ^{[1
]}

Song, Fei-Yi ^{[1
]}

Liou, Chien-Chung ^{[1
]}

Wu, Yu-Shan ^{[1
]}

机构：

[1] Tunghai Univ, Dept Chem, Taichung 407, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 12期

关键词：

Antimicrobial peptides; Ixosin-B; Antimicrobial activity; Hemolytic activity; CATIONIC PEPTIDES; MEMBRANES; DEFENSE;

D O I：

10.1016/j.bmcl.2012.04.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antimicrobial peptides (AMPs) represent the first defense line against infection when organisms are infected by pathogens. These peptides are generally good targets for the development of antimicrobial agents. Peptide amide analogs of Ixosin-B, an antimicrobial peptide with amino acid sequence of QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY, were designed, synthesized and examined for antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Within the peptides synthesized, we discovered an 11-mer peptide, KRLRRVWRRWR-amide, which exhibited potent antimicrobial activity while very little hemolytic activity in human erythrocytes was observed even at high dose level (100 mu M). With further modifications, this peptide could be developed into a potent antimicrobial agent in the future. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：4185 / 4188

页数：4

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