Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis

被引：91

作者：

Goyal, Tanu ^{[1
,2
,3
]}

Mitra, Sona ^{[1
,2
,3
]}

Khaidakov, Magomed ^{[1
,2
,3
]}

Wang, Xianwei ^{[1
,2
,3
]}

Singla, Sandeep ^{[1
,2
,3
]}

Ding, Zufeng ^{[1
,2
,3
]}

Liu, Shijie ^{[1
,2
,3
]}

Mehta, Jawahar L. ^{[1
,2
,3
]}

机构：

[1] UAMS, Div Cardiovasc, Little Rock, AR 72212 USA

[2] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[3] Cent Arkansas Vet Hlth Syst, Little Rock, AR USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2012年 / 14卷 / 02期

关键词：

Atherosclerosis; Scavenger receptors; SRA-1; CD36; LOX1; LOW-DENSITY-LIPOPROTEIN; MACROPHAGE SCAVENGER RECEPTORS; MONOCYTE-DERIVED MACROPHAGES; ARTERY ENDOTHELIAL-CELLS; ACUTE CORONARY SYNDROME; UP-REGULATION; NITRIC-OXIDE; OX-LDL; INDUCED EXPRESSION; OXIDATIVE STRESS;

D O I：

10.1007/s11883-012-0228-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.

引用

页码：150 / 159

页数：10

共 82 条

[1]

[Anonymous], 2008, SSCI P 2008

[2] Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A [J].