Improved Outcomes of Kidney Transplantation in Infants (Age < 2 years): A Single-Center Experience

被引：19
作者：
Chavers, Blanche M. [1 ]
Rheault, Michelle N. [1 ]
Matas, Arthur J. [2 ]
Jackson, Scott C. [3 ]
Cook, Marie E. [2 ]
Nevins, Thomas E. [1 ]
Najarian, John S. [2 ]
Chinnakotla, Srinath [2 ]
机构：
[1] Univ Minnesota, Div Pediat Nephrol, Minneapolis, MN USA
[2] Univ Minnesota, Dept Surg, Box 242 UMHC, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Transplant Informat Serv, Minneapolis, MN USA
来源：
TRANSPLANTATION | 2018年 / 102卷 / 02期
关键词：
STAGE RENAL-DISEASE; CHILDREN LESS; REPLACEMENT THERAPY; PERITONEAL-DIALYSIS; RECIPIENTS; COMPLICATIONS; MAINTENANCE; FAILURE; GROWTH; RATES;
D O I：
10.1097/TP.0000000000001929
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. Infants (age, < 2 years) with end-stage renal disease (ESRD) have increased morbidity and mortality. We evaluated our long-term outcomes of kidney transplants (KTx) in infants. Methods. Between 1984 and 2014, 136 infants underwent KTx. We examined trends in survival rates and complications by era (1984-1993 [era 1], 1994-2003 [era 2], 2004-2014 [era 3]). Results. Patients were 92.6% white and 70.6% males. Posttransplant (Tx) initial length of hospital stay declined 37% over the 30-year period (P < 0.01). Ten-year death-censored graft survival improved from 60% (era 1) to 80% (era 2) (P = 0.04). The incidence of acute rejection, graft thrombosis, cytomegalovirus, and urine leaks did not significantly change across eras. Frequency of Epstein-Barr virus diagnosis (era 2 vs era 3, P < 0.01) increased. Post-Tx lymphoproliferative disorder incidence was increased in era 2 compared with eras 1 and 3 (P = 0.03). Conclusions. Infants deserve earlier consideration for KTx. Length of initial hospital stay and patient and graft survival rates after KTx have improved in infants since 1984.
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收藏
页码：284 / 290
页数：7
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