A new highly oxygenated pregnane and two new 5-hydroxymethylfurfural derivatives from the water decoction of Poria cocos

被引：6
作者：
Chen, Ting [1 ,2 ,3 ]
Kan, Yong-Jun [4 ]
Chou, Gui-Xin [1 ,2 ,3 ]
Zhang, Cheng-Gang [1 ,2 ,3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China
[3] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China
[4] Fujian Acad Chinese Med, Inst Drug Res, Fuzhou 350003, Fujian, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 12期
关键词：
Polyporaceae; Poria cocos; pregnane steroid; 5-hydroxymethylfurfural derivatives; alpha-glucosidase; LANOSTANE TRITERPENOIDS;
D O I：
10.1080/10286020.2017.1383398
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new highly oxygenated pregnane steroid, pregn-7-ene-2 beta,3 alpha,15 alpha,20-tetrol (1) and two new 5-hydroxymethylfurfural derivatives, (5-formylfuran-2-yl)methyl 2-hydroxypropanoate (2) and (5-formylfuran-2-yl)methyl 2-(4-hydroxyphenyl)acetate (3), together with four known compounds, were isolated from the water decoction of Poria cocos. Their structures were established on the basis of extensive spectroscopic analysis. Compound 1 showed moderate inhibitory activity and a known compound (3S,6S)-3-[(1R)-1-hydroxyethyl]-6-(phenylmethyl)-2,5-piperazinedione (5) showed weak inhibitory activity against alpha-glucosidase, respectively. [GRAPHICS] .
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收藏
页码：1101 / 1107
页数：7
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