Genetics of Chronic Lymphocytic Leukemia

被引：6

作者：

Schnaiter, Andrea ^{[1
]}

Mertens, Daniel ^{[1
]}

Stilgenbauer, Stephan ^{[1
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

来源：

CLINICS IN LABORATORY MEDICINE | 2011年 / 31卷 / 04期

关键词：

CLL; Genetics; TP53; ATM; IGHV; FISH; MUTATION STATUS; GENOMIC ABERRATIONS; PROGNOSTIC SUBGROUPS; CLONAL EVOLUTION; CD38; EXPRESSION; 11Q DELETION; SURVIVAL; CLL; FLUDARABINE; RESISTANCE;

D O I：

10.1016/j.cll.2011.07.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Morphology and the immunophenotype of chronic lymphocytic leukemia (CLL) are quite homogenous, but CLL's clinical course is not; some patients are stable for years, others experience rapid progression and poor response to chemotherapy. Fluorescence in situ hybridization (FISH) helped determine why these differences occur. Further progress has been made using comparative genomic hybridization and single nucleotide polymorphism (SNP) array analysis. Now the discovery of further dysregulated cellular pathways and potential new therapeutic targets is possible by genome-wide high-throughput next generation sequencing, which will likely also enter clinical diagnostics.

引用

页码：649 / +

页数：11

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