KRAS Oncogenic Signaling Extends beyond Cancer Cells to Orchestrate the Microenvironment

被引：147
作者：
Carvalho, Patricia Dias [1 ,2 ]
Guimaraes, Carlos F. [1 ,2 ]
Cardoso, Ana P. [1 ,3 ]
Mendonca, Susana [1 ,2 ]
Costa, Angela M. [1 ,3 ]
Oliveira, Maria J. [1 ,3 ,4 ]
Velho, Sergia [1 ,2 ]
机构：
[1] Univ Porto, i3S, Porto, Portugal
[2] Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, Porto, Portugal
[3] Univ Porto, INEB Inst Biomed Engn, Porto, Portugal
[4] Univ Porto, Fac Med, Porto, Portugal
来源：
CANCER RESEARCH | 2018年 / 78卷 / 01期
关键词：
MUTANT K-RAS; ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; PANCREATIC-CANCER; EXTRACELLULAR-MATRIX; COLORECTAL-CANCER; T-CELLS; TUMOR MICROENVIRONMENT; GENE-EXPRESSION; MYELOID CELLS;
D O I：
10.1158/0008-5472.CAN-17-2084
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to therapy. Despite the large investment to understand the effects of KRAS activation in cancer cells, pharmacologic targeting of KRAS or its downstream effectors has not yet been successful at the clinical level. Recent studies are now describing new mechanisms of KRAS-induced tumorigenesis by analyzing its effects on the components of the tumor microenvironment. These studies revealed that the activation of KRAS on cancer cells extends to the surrounding microenvironment, affecting the properties and functions of its constituents. Herein, we discuss the most emergent perspectives on the relationship between KRAS-mutant cancer cells and their microenvironment components. (C) 2017 AACR.
引用
收藏
页码：7 / 14
页数：8
相关论文
共 95 条
  • [1] Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations
    Abrams, SI
    Khleif, SN
    Bergmann-Leitner, ES
    Kantor, JA
    Chung, Y
    Hamilton, JM
    Schlom, J
    [J]. CELLULAR IMMUNOLOGY, 1997, 182 (02) : 137 - 151
  • [2] [Anonymous], J CLIN ONCOL S
  • [3] [Anonymous], CANC IMMUNOL IMMUNOT
  • [4] [Anonymous], TRENDS CANC
  • [5] BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer
    Bartolini, Alice
    Cardaci, Sabrina
    Lamba, Simona
    Oddo, Daniele
    Marchio, Caterina
    Cassoni, Paola
    Amoreo, Carla Azzurra
    Corti, Giorgio
    Testori, Alessandro
    Bussolino, Federico
    Pasqualini, Renata
    Arap, Wadih
    Cora, Davide
    Di Nicolantonio, Federica
    Marchio, Serena
    [J]. CLINICAL CANCER RESEARCH, 2016, 22 (19) : 4923 - 4933
  • [6] Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
    Bayne, Lauren J.
    Beatty, Gregory L.
    Jhala, Nirag
    Clark, Carolyn E.
    Rhim, Andrew D.
    Stanger, Ben Z.
    Vonderheide, Robert H.
    [J]. CANCER CELL, 2012, 21 (06) : 822 - 835
  • [7] Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS
    Beckler, Michelle Demory
    Higginbotham, James N.
    Franklin, Jeffrey L.
    Ham, Amy-Joan
    Halvey, Patrick J.
    Imasuen, Imade E.
    Whitwell, Corbin
    Li, Ming
    Liebler, Daniel C.
    Coffey, Robert J.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2013, 12 (02) : 343 - 355
  • [8] Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele
    Bergmann-Leitner, ES
    Kantor, JA
    Shupert, WL
    Schlom, J
    Abrams, SI
    [J]. CELLULAR IMMUNOLOGY, 1998, 187 (02) : 103 - 116
  • [9] Regulatory T cells in cancer
    Beyer, Marc
    Schultze, Joachim L.
    [J]. BLOOD, 2006, 108 (03) : 804 - 811
  • [10] Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    Bissell, Mina J.
    Hines, William C.
    [J]. NATURE MEDICINE, 2011, 17 (03) : 320 - 329
12345678910