KRAS Oncogenic Signaling Extends beyond Cancer Cells to Orchestrate the Microenvironment

被引：151

作者：

Carvalho, Patricia Dias ^{[1
,2
]}

Guimaraes, Carlos F. ^{[1
,2
]}

Cardoso, Ana P. ^{[1
,3
]}

Mendonca, Susana ^{[1
,2
]}

Costa, Angela M. ^{[1
,3
]}

Oliveira, Maria J. ^{[1
,3
,4
]}

Velho, Sergia ^{[1
,2
]}

机构：

[1] Univ Porto, i3S, Porto, Portugal

[2] Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, Porto, Portugal

[3] Univ Porto, INEB Inst Biomed Engn, Porto, Portugal

[4] Univ Porto, Fac Med, Porto, Portugal

来源：

CANCER RESEARCH | 2018年 / 78卷 / 01期

关键词：

MUTANT K-RAS; ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; PANCREATIC-CANCER; EXTRACELLULAR-MATRIX; COLORECTAL-CANCER; T-CELLS; TUMOR MICROENVIRONMENT; GENE-EXPRESSION; MYELOID CELLS;

D O I：

10.1158/0008-5472.CAN-17-2084

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to therapy. Despite the large investment to understand the effects of KRAS activation in cancer cells, pharmacologic targeting of KRAS or its downstream effectors has not yet been successful at the clinical level. Recent studies are now describing new mechanisms of KRAS-induced tumorigenesis by analyzing its effects on the components of the tumor microenvironment. These studies revealed that the activation of KRAS on cancer cells extends to the surrounding microenvironment, affecting the properties and functions of its constituents. Herein, we discuss the most emergent perspectives on the relationship between KRAS-mutant cancer cells and their microenvironment components. (C) 2017 AACR.

引用

页码：7 / 14

页数：8

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