Single-Scan 13C Diffusion- Ordered NMR Spectroscopy of DNP-Hyperpolarised Substrates

被引：30

作者：

Guduff, Ludmilla ^{[1
]}

Kurzbach, Dennis ^{[2
,3
]}

van Heijenoort, Carine ^{[1
]}

Abergel, Daniel ^{[2
,3
]}

Dumez, Jean-Nicolas ^{[1
]}

机构：

[1] Univ Paris Saclay, Univ Paris Sud, Inst Chim Subst Nat, CNRS,UPR2301, F-91190 Gif Sur Yvette, France

[2] PSL Res Univ, UPMC Univ Paris 06, Ecole Normale Super, Lab Biomol,Dept Chim,CNRS, F-75005 Paris, France

[3] UPMC Univ Paris 06, Sorbonne Univ, Ecole Normale Super, Lab Biomol,CNRS, F-75005 Paris, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 66期

基金：

欧洲研究理事会;

关键词：

diffusion-ordered spectroscopy (DOSY); dynamic nuclear polarisation; hyperpolarisation; NMR; DYNAMIC NUCLEAR-POLARIZATION; MAGNETIC-RESONANCE-SPECTROSCOPY; FIELD GRADIENT NMR; LIQUID-STATE NMR; DOSY-NMR; PARA-HYDROGEN; MIXTURES; TOOL; COEFFICIENTS; CONVECTION;

D O I：

10.1002/chem.201703300

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diffusion-ordered NMR spectroscopy (DOSY) is a powerful approach for the analysis of molecular mixtures, yet its application range is limited by the relatively low sensitivity of NMR. We show here that spectrally resolved C-13 DOSY data can be collected, in a single scan, for substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP), which provides signal enhancements of several orders of magnitude. For this we use a convection-compensation pulse scheme, which we also analyse by numerical simulation. The proposed method further allows the acquisition of several consecutive DOSY spectra in a single D-DNP experiment.

引用

页码：16722 / 16727

页数：6

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