Effects of Artemisinin Dimers on Rat Breast Cancer Cells In Vitro and In Vivo

被引：1

作者：

Singh, Narendra P. ^{[2
]}

Lai, Henry C. ^{[2
]}

Park, Ji Sun ^{[2
]}

Gerhardt, Thomas E. ^{[2
]}

Kim, Byung Ju ^{[1
]}

Wang, Shusheng ^{[1
]}

Sasaki, Tomikazu ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

ANTICANCER RESEARCH | 2011年 / 31卷 / 12期

关键词：

Artemisinin dimers; dihydroartemisinin; rat; breast cancer cells; TRIOXANE DIMERS; ANTICANCER ACTIVITY; HIGH-STABILITY; ANTIMALARIAL; DIHYDROARTEMISININ; CYTOTOXICITY; EFFICACY; HOLOTRANSFERRIN; DERIVATIVES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Artemisinin has been shown to be an effective antimalarial and anticancer compound. Dimers of artemisinin have been synthesized and shown to be potent antimalarials compared with monomers. In the present study, we investigated the effect of two artemisinin dimers (dimer-alcohol and dimer-hydrazone) on rat mammary adenocarcinoma cells (MTLn3) in vitro and in vivo compared with that of the artemisinin monomer dihydroartemisinin (DHA). We found that the dimers are considerably more potent than DHA in killing MTLn3 cells in vitro and suppressing the growth of MTLn3 breast tumors in vivo.

引用

页码：4111 / 4114

页数：4

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