Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

被引：18

作者：

Thomas, Santana A. L. ^{[1
,3
]}

von Salm, Jacqueline L. ^{[1
,3
]}

Clark, Shane ^{[1
]}

Ferlita, Steve ^{[1
]}

Nemani, Prasanth ^{[1
]}

Azhari, Ala ^{[2
,3
]}

Rice, Christopher A. ^{[2
,3
]}

Wilson, Nerida G. ^{[4
,5
]}

Kyle, Dennis E. ^{[2
,3
]}

Baker, Bill J. ^{[1
,3
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Dept Global Hlth, Tampa, FL 33620 USA

[3] Univ S Florida, Ctr Drug Discovery & Innovat, Tampa, FL 33620 USA

[4] Western Australian Museum, Perth, WA 6009, Australia

[5] Univ Western Australia, Perth, WA 6009, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 01期

基金：

美国国家科学基金会;

关键词：

MARINE NATURAL-PRODUCTS; ANTHOZOA; SESQUITERPENES; COELENTERATA; CHEMISTRY; CNIDARIA;

D O I：

10.1021/acs.jnatprod.7b00732

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 mu M. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

引用

页码：117 / 123

页数：7

共 30 条

[1] STRUCTURE ACTIVITY AND MOLECULAR MODELING STUDIES OF THE LOPHOTOXIN FAMILY OF IRREVERSIBLE NICOTINIC RECEPTOR ANTAGONISTS
ABRAMSON, SN
TRISCHMAN, JA
TAPIOLAS, DM
HAROLD, EE
FENICAL, W
TAYLOR, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (06) : 1798 - 1804
[2] Bandurraga M. M., 1982, THESIS
[3] Marine natural products
Blunt, John W.
Copp, Brent R.
Keyzers, Robert A.
Munro, Murray H. G.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2017, 34 (03) : 235 - 294
[4] STUDIES OF AUSTRALIAN SOFT CORALS .44. NEW DITERPENES FROM SINULARIA-POLYDACTYLA (COELENTERATA, ANTHOZOA, OCTOCORALLIA)
BOWDEN, BF
COLL, JC
WRIGHT, AD
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (05) : 757 - 763
[5] Bruker, 2016, APEX3 2015 9
[6] Bruker, 2016, SAINT 8 35A
[7] THE CHEMISTRY AND CHEMICAL ECOLOGY OF OCTOCORALS (COELENTERATA, ANTHOZOA, OCTOCORALLIA)
COLL, JC
[J]. CHEMICAL REVIEWS, 1992, 92 (04) : 613 - 631
[8] OLEX2: a complete structure solution, refinement and analysis program
Dolomanov, Oleg V.
Bourhis, Luc J.
Gildea, Richard J.
Howard, Judith A. K.
Puschmann, Horst
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2009, 42 : 339 - 341
[9] A novel cytotoxic norditerpenoid from the Formosan soft coral Sinularia inelegans
Duh, CY
Wang, SK
Chia, MC
Chiang, MY
[J]. TETRAHEDRON LETTERS, 1999, 40 (33) : 6033 - 6035
[10] DNA sequences of the mitochondrial COI gene have low levels of divergence among deep-sea octocorals (Cnidaria: Anthozoa)
France, SC
Hoover, LL
[J]. HYDROBIOLOGIA, 2002, 471 (1-3) : 149 - 155

← 1 2 3 →