The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome

被引：150

作者：

D'Souza, Anita ^{[1
]}

Hayman, Suzanne R. ^{[1
]}

Buadi, Francis ^{[1
]}

Mauermann, Michelle ^{[2
]}

Lacy, Martha Q. ^{[1
]}

Gertz, Morie A. ^{[1
]}

Kyle, Robert A. ^{[1
]}

Kumar, Shaji ^{[1
]}

Greipp, Philip R. ^{[1
]}

Lust, John A. ^{[1
]}

Russell, Stephen J. ^{[1
]}

Zeldenrust, Steven ^{[1
]}

Dingli, David ^{[1
]}

Witzig, Thomas E. ^{[1
]}

Rajkumar, S. Vincent ^{[1
]}

Dispenzieri, Angela ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

来源：

BLOOD | 2011年 / 118卷 / 17期

关键词：

STEM-CELL-TRANSPLANTATION; SERUM VEGF LEVELS; PLATELETS; DISEASE; OVERPRODUCTION;

D O I：

10.1182/blood-2011-06-362392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given variable platelet release of VEGF. We therefore compared plasma levels of VEGF in 29 patients with POEMS syndrome with those of other disorders (n = 76). We demonstrated that plasma VEGF levels are useful in differentiating POEMS from other plasma cell dyscrasias, neuropathic processes, and multisystem illnesses. Plasma VEGF is also useful in monitoring disease activity after treatment and correlates with clinical improvements better than hematologic response. (Blood. 2011; 118(17): 4663-4665)

引用

页码：4663 / 4665

页数：3

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