The Function, Regulation and Mechanism of Programmed Cell Death of Macrophages in Atherosclerosis

被引：22

作者：

Liu, Chang ^{[1
]}

Jiang, Zecheng ^{[1
]}

Pan, Zhongjie ^{[2
]}

Yang, Liang ^{[1
]}

机构：

[1] Nankai Univ, Sch Med, Dept Pharmacol, Tianjin, Peoples R China

[2] Tianjin Union Med Ctr, Tianjin, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

atherosclerosis; macrophage; programmed cell death; apoptosis; autophagy; pyroptosis; ferroptosis; necroptosis; APOPTOTIC CELLS; AUTOPHAGY; NECROSIS; EFFEROCYTOSIS; INFLAMMATION; PATHOGENESIS; NECROPTOSIS; SUPPRESSION; PROGRESSION; FERROPTOSIS;

D O I：

10.3389/fcell.2021.809516

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Atherosclerosis is a chronic progressive inflammatory vascular disease, which is an important pathological basis for inducing a variety of cardio-cerebrovascular diseases. As a kind of inflammatory cells, macrophages are the most abundant immune cells in atherosclerotic plaques and participate in the whole process of atherosclerosis and are the most abundant immune cells in atherosclerotic plaques. Recent studies have shown that programmed cell death plays a critical role in the progression of many diseases. At present, it is generally believed that the programmed death of macrophages can affect the development and stability of atherosclerotic vulnerable plaques, and the intervention of macrophage death may become the target of atherosclerotic therapy. This article reviews the role of macrophage programmed cell death in the progression of atherosclerosis and the latest therapeutic strategies targeting macrophage death within plaques.

引用

页数：11

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