Etiology and pathogenesis of multiple sclerosis

被引：39
作者：
Sorensen, TL
Ransohoff, RM
机构：
[1] Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci NC30, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Mellen Ctr Multiple Sclerosis Treatment & Res, Cleveland, OH 44195 USA
[3] Univ Copenhagen, Glostrup Hosp, Dept Neurol, DK-2600 Glostrup, Denmark
来源：
SEMINARS IN NEUROLOGY | 1998年 / 18卷 / 03期
关键词：
multiple sclerosis; pathogenesis;
D O I：
10.1055/s-2008-1040879
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The cause of multiple sclerosis (MS) remains unknown despite decades of intense research, The major research disciplines that have been brought to bear on this question include genetics, epidemiology, neuropathology, immunology, and virology, Recent advances in the understanding of the inflammatory characteristics of the MS lesion may herald the development of specific and effective treatments. The goal of this research is to improve our management of a disease that remains the major cause of neurologic disability among young adults in North America and Europe.
引用
收藏
页码：287 / 294
页数：8
相关论文
共 86 条
[1]   T-CELLS RESPONSIVE TO MYELIN BASIC-PROTEIN IN PATIENTS WITH MULTIPLE-SCLEROSIS [J].
ALLEGRETTA, M ;
NICKLAS, JA ;
SRIRAM, S ;
ALBERTINI, RJ .
SCIENCE, 1990, 247 (4943) :718-721
[2]  
ALLEGRETTA M, 1994, J CLIN INVEST
[3]   CYTOKINES IN THE CENTRAL-NERVOUS-SYSTEM OF MICE DURING CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS [J].
BAKER, D ;
ONEILL, JK ;
TURK, JL .
CELLULAR IMMUNOLOGY, 1991, 134 (02) :505-510
[4]   A new class of membrane-bound chemokine with a CX(3)C motif [J].
Bazan, JF ;
Bacon, KB ;
Hardiman, G ;
Wang, W ;
Soo, K ;
Rossi, D ;
Greaves, DR ;
Zlotnik, A ;
Schall, TJ .
NATURE, 1997, 385 (6617) :640-644
[5]   INCREASED PRODUCTION OF INTERFERON GAMMA AND TUMOR NECROSIS FACTOR PRECEDES CLINICAL MANIFESTATION IN MULTIPLE-SCLEROSIS - DO CYTOKINES TRIGGER OFF EXACERBATIONS [J].
BECK, J ;
RONDOT, P ;
CATINOT, L ;
FALCOFF, E ;
KIRCHNER, H ;
WIETZERBIN, J .
ACTA NEUROLOGICA SCANDINAVICA, 1988, 78 (04) :318-323
[6]   Multiple loci for multiple sclerosis [J].
Bell, JI ;
Lathrop, GM .
NATURE GENETICS, 1996, 13 (04) :377-378
[7]   DETECTION OF MHC CLASS-II ANTIGENS ON MACROPHAGES AND MICROGLIA, BUT NOT ON ASTROCYTES AND ENDOTHELIA IN ACTIVE MULTIPLE-SCLEROSIS LESIONS [J].
BO, L ;
MORK, S ;
KONG, PA ;
NYLAND, H ;
PARDO, CA ;
TRAPP, BD .
JOURNAL OF NEUROIMMUNOLOGY, 1994, 51 (02) :135-146
[8]   INDUCTION OF NITRIC-OXIDE SYNTHASE IN DEMYELINATING REGIONS OF MULTIPLE-SCLEROSIS BRAINS [J].
BO, L ;
DAWSON, TM ;
WESSELINGH, S ;
MORK, S ;
CHOI, S ;
KONG, PA ;
HANLEY, D ;
TRAPP, BD .
ANNALS OF NEUROLOGY, 1994, 36 (05) :778-786
[9]  
BO L, 1996, J NEUROL EXP NEUROPA, V55, P1066
[10]   INDUCTION OF RELAPSING PARALYSIS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY BACTERIAL SUPERANTIGEN [J].
BROCKE, S ;
GAUR, A ;
PIERCY, C ;
GAUTAM, A ;
GIJBELS, K ;
FATHMAN, CG ;
STEINMAN, L .
NATURE, 1993, 365 (6447) :642-644
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