Dynamic kinetic resolution

被引：123
作者：
El Gihani, MT [1 ]
Williams, JMJ [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(99)80003-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.
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页码：11 / 15
页数：5
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