Synthesis of N,O-heterocycles by intramolecular conjugate addition of a hydroxylamine

被引：17

作者：

Bates, Roderick W. ^{[1
]}

Snell, Robert H. ^{[1
]}

Winbush, SusAnn ^{[2
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

[2] Chulabhorn Res Inst, Med Chem Lab, Bangkok 10210, Thailand

来源：

SYNLETT | 2008年 / 07期

关键词：

Michael addition; hydroxylamine; oxazine;

D O I：

10.1055/s-2008-1072650

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazolidines and tetrahydro-1,2-oxazines were produced by a tandem deprotection-intramolecular Michael addition of hydroxylamines. For tetrahydrooxazine formation, high stereoselectivity was observed, even when a quaternary centre was formed.

引用

页码：1042 / 1044

页数：3

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