COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients

被引：159

作者：

Haerter, Georg ^{[1
]}

Spinner, Christoph D. ^{[2
]}

Roider, Julia ^{[3
,4
]}

Bickel, Markus ^{[5
]}

Krznaric, Ivanka ^{[6
]}

Grunwald, Stephan ^{[6
]}

Schabaz, Farhad ^{[7
]}

Gillor, Daniel ^{[8
]}

Postel, Nils ^{[9
]}

Mueller, Matthias C. ^{[10
,11
]}

Mueller, Markus

Roemer, Katja

Schewe, Knud ^{[12
]}

Hoffmann, Christian ^{[12
,13
]}

机构：

[1] Medicover Ulm MVZ, Munsterpl 6, D-89073 Ulm, Germany

[2] Tech Univ Munich, Univ Hosp Klinikum Rechts Isar, Sch Med, Dept Med 2, Ismaninger Str 22, D-81675 Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Klinikum Univ, Med Klin & Poliklin 4, Sekt Klin Infektiol, Pettenkoferstr 8a, D-80336 Munich, Germany

[4] Partner Site Munich, German Ctr Infect Res DZIF, Munich, Germany

[5] Infektiologikum Frankfurt, Stresemannallee 3, D-60596 Frankfurt, Germany

[6] Zentrum Infektiol Berlin Prenzelberg, Driesener Str 11, D-10439 Berlin, Germany

[7] MVZ Karlspl Munchen, Karlspl 8, D-80335 Munich, Germany

[8] MVZ Innere Med Koln, Hohenstaufenring 59, D-50674 Cologne, Germany

[9] Prinzmed, Sendlinger Tor Pl 8, D-80336 Munich, Germany

[10] MVZ Clotten, Dept Infect Med, Med Care Ctr, Berliner Allee 29, D-79110 Freiburg, Germany

[11] Univ Freiburg, Fac Med, Med Ctr, Dept Med 2,Div Infect Dis, Hugstetter Str 55, D-79106 Freiburg, Germany

[12] ICH Study Ctr Hamburg, Glockengiesserwall 1, D-20095 Hamburg, Germany

[13] Univ Hosp Schleswig Holstein, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany

来源：

INFECTION | 2020年 / 48卷 / 05期

关键词：

SARS-CoV-2; COVID-19; HIV infection; AIDS; Antiretroviral therapy; CORONAVIRUS DISEASE 2019; INFECTION;

D O I：

10.1007/s15010-020-01438-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. Methods Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. Results Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. Conclusions This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.

引用

页码：681 / 686

页数：6

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