COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients

被引:162
作者
Haerter, Georg [1 ]
Spinner, Christoph D. [2 ]
Roider, Julia [3 ,4 ]
Bickel, Markus [5 ]
Krznaric, Ivanka [6 ]
Grunwald, Stephan [6 ]
Schabaz, Farhad [7 ]
Gillor, Daniel [8 ]
Postel, Nils [9 ]
Mueller, Matthias C. [10 ,11 ]
Mueller, Markus
Roemer, Katja
Schewe, Knud [12 ]
Hoffmann, Christian [12 ,13 ]
机构
[1] Medicover Ulm MVZ, Munsterpl 6, D-89073 Ulm, Germany
[2] Tech Univ Munich, Univ Hosp Klinikum Rechts Isar, Sch Med, Dept Med 2, Ismaninger Str 22, D-81675 Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Klinikum Univ, Med Klin & Poliklin 4, Sekt Klin Infektiol, Pettenkoferstr 8a, D-80336 Munich, Germany
[4] Partner Site Munich, German Ctr Infect Res DZIF, Munich, Germany
[5] Infektiologikum Frankfurt, Stresemannallee 3, D-60596 Frankfurt, Germany
[6] Zentrum Infektiol Berlin Prenzelberg, Driesener Str 11, D-10439 Berlin, Germany
[7] MVZ Karlspl Munchen, Karlspl 8, D-80335 Munich, Germany
[8] MVZ Innere Med Koln, Hohenstaufenring 59, D-50674 Cologne, Germany
[9] Prinzmed, Sendlinger Tor Pl 8, D-80336 Munich, Germany
[10] MVZ Clotten, Dept Infect Med, Med Care Ctr, Berliner Allee 29, D-79110 Freiburg, Germany
[11] Univ Freiburg, Fac Med, Med Ctr, Dept Med 2,Div Infect Dis, Hugstetter Str 55, D-79106 Freiburg, Germany
[12] ICH Study Ctr Hamburg, Glockengiesserwall 1, D-20095 Hamburg, Germany
[13] Univ Hosp Schleswig Holstein, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany
关键词
SARS-CoV-2; COVID-19; HIV infection; AIDS; Antiretroviral therapy; CORONAVIRUS INFECTION;
D O I
10.1007/s15010-020-01438-z
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Introduction Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. Methods Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. Results Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. Conclusions This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.
引用
收藏
页码:681 / 686
页数:6
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