HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy

被引：38

作者：

Jafari, Ameneh ^{[1
,2
]}

Rezaei-Tavirani, Mostafa ^{[2
]}

Farhadihosseinabadi, Behrouz ^{[3
]}

Taranejoo, Shahrouz ^{[4
]}

Zali, Hakimeh ^{[5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Sch Allied Med Sci, Darband St, Tehran, Iran

[3] Iran Univ Med Sci, Neurosci Res Ctr NRC, Tehran, Iran

[4] Harvard MIT Div Hlth Sci & Technol HST, Wellman Ctr Photomed, Boston, MA USA

[5] Shahid Beheshti Univ Med Sci, Dept Tissue Engn & Appl Cell, Sch Adv Technol Med, Tehran, Iran

来源：

CANCER INVESTIGATION | 2020年 / 38卷 / 05期

关键词：

HSP90; inhibitor; cancer; targeted therapy; tumor biomarker; client protein; SHOCK-PROTEIN; 90; BREAST-CANCER; LUNG-CANCER; POSTTRANSLATIONAL MODIFICATIONS; HEAT-SHOCK-PROTEIN-90; HSP90; SIGNALING PATHWAYS; HUMAN TELOMERASE; CELL-GROWTH; PHASE-II; KAPPA-B;

D O I：

10.1080/07357907.2020.1752227

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a double-edged sword. It plays an essential role in many physiological and pathological processes, including tumor development. The current review highlights a recent understanding of the roles of HSP90 in molecular mechanisms underlying cancer survival and progression. HSP90 and its client proteins through the regulation of oncoproteins including signaling proteins, receptors, and transcriptional factors involved in tumorigenesis. It also has potential clinical application as diagnostic and prognostic biomarkers for assessing cancer progression. In this way, using HSP90 to develop new anticancer therapeutic agents including HSP90 inhibitors, anti-HSP90 antibody, and HSP90-based vaccines has been promising.

引用

页码：310 / 328

页数：19

共 169 条

[1] Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds [J].

Amin, A. R. M. Ruhul ;

Karpowicz, Phillip A. ;

Carey, Thomas E. ;

Arbiser, Jack ;

Nahta, Rita ;

Chen, Zhuo G. ;

Dong, Jin-Tang ;

Kucuk, Omer ;

Khan, Gazala N. ;

Huang, Gloria S. ;

Mi, Shijun ;

Lee, Ho-Young ;

Reichrath, Joerg ;

Honoki, Kanya ;

Georgakilas, Alexandros G. ;

Amedei, Amedeo ;

Amin, Amr ;

Helferich, Bill ;

Boosani, Chandra S. ;

Ciriolo, Maria Rosa ;

Chen, Sophie ;

Mohammed, Sulma I. ;

Azmis, Asfar S. ;

Keith, W. Nicol ;

Bhakta, Dipita ;

Halicka, Dorota ;

Niccolai, Elena ;

Fujii, Hiromasa ;

Aquilano, Katia ;

Ashraf, S. Salman ;

Nowsheen, Somaira ;

Yang, Xujuan ;

Bilsland, Alan ;

Shin, Dong M. .

SEMINARS IN CANCER BIOLOGY, 2015, 35 :S55-S77

[2] Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins [J].

Ardi, Veronica C. ;

Alexander, Leslie D. ;

Johnson, Victoria A. ;

McAlpine, Shelli R. .

ACS CHEMICAL BIOLOGY, 2011, 6 (12) :1357-1366

[3] In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex [J].

Averna, Monica ;

Stifanese, Roberto ;

De Tullio, Roberta ;

Salamino, Franca ;

Pontremoli, Sandro ;

Melloni, Edon .

FEBS JOURNAL, 2008, 275 (10) :2501-2511

[4]

Azoitei Ninel, 2015, Mol Cell Oncol, V2, pe981444, DOI 10.4161/23723556.2014.981444

[5] HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization [J].

Azoitei, Ninel ;

Diepold, Kristina ;

Brunner, Cornelia ;

Rouhi, Arefeh ;

Genze, Felicitas ;

Becher, Alexander ;

Kestler, Hans ;

van Lint, Johan ;

Chiosis, Gabriela ;

Koren, John, III ;

Froehling, Stefan ;

Scholl, Claudia ;

Seufferlein, Thomas .

CANCER RESEARCH, 2014, 74 (23) :7125-7136

[6] Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis [J].

Baker-Williams, Alexander J. ;

Hashmi, Fiza ;

Nski, Marek A. Budzy ;

Woodford, Mark R. ;

Gleicher, Stephanie ;

Himanen, Samu V. ;

Makedon, Alan M. ;

Friedman, Derek ;

Cortes, Stephanie ;

Namek, Sara ;

Stetler-Stevenson, William G. ;

Bratslavsky, Gennady ;

Bah, Alaji ;

Mollapour, Mehdi ;

Sistonen, Lea ;

Bourboulia, Dimitra .

CELL REPORTS, 2019, 28 (07) :1894-+

[7] Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models [J].

Banerji, U ;

Walton, M ;

Raynaud, F ;

Grimshaw, R ;

Kelland, L ;

Valenti, M ;

Judson, I ;

Workman, P .

CLINICAL CANCER RESEARCH, 2005, 11 (19) :7023-7032

[8] Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function [J].

Basso, AD ;

Solit, DB ;

Chiosis, G ;

Giri, B ;

Tsichlis, P ;

Rosen, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39858-39866

[9] Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases [J].

Bohush, Anastasiia ;

Bieganowski, Pawel ;

Filipek, Anna .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (20)

[10] Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models [J].

Caldas-Lopes, Eloisi ;

Cerchietti, Leandro ;

Ahn, James H. ;

Clement, Cristina C. ;

Robles, Ana I. ;

Rodina, Anna ;

Moulick, Kamalika ;

Taldone, Tony ;

Gozman, Alexander ;

Guo, Yunke ;

Wu, Nian ;

de Stanchina, Elisa ;

White, Julie ;

Gross, Steven S. ;

Ma, Yuliang ;

Varticovski, Lyuba ;

Melnick, Ari ;

Chiosis, Gabriela .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (20) :8368-8373

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