Effects of tumor necrosis factor alpha on Sin Nombre virus infection in vitro

被引：61
作者：
Khaiboullina, SF
Netski, DM
Krumpe, P
St Jeor, SC [1 ]
机构：
[1] Univ Nevada, Dept Microbiol, Reno, NV 89557 USA
[2] Univ Nevada, Sch Med, Cell & Mol Biol Program, Reno, NV 89557 USA
[3] Vet Affairs Sierra Nevada Hlth Care Syst, Reno, NV USA
来源：
JOURNAL OF VIROLOGY | 2000年 / 74卷 / 24期
关键词：
D O I：
10.1128/JVI.74.24.11966-11971.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Previous data indicate that immune mechanisms may be involved in developing capillary leakage during Sin Nombre virus (SNV) infection. Therefore, we investigated production of tumor necrosis factor alpha (TNF-alpha) by human alveolar macrophages and human umbilical vein endothelial cells (HUVEC) after infection with SNV. In addition, we examined the effect of TNF-alpha on HUVEC monolayer leakage. Our results reveal that although TNF-alpha decreases accumulation of viral nucleoproteins, TNF-alpha levels do not change in SNV-infected cells. In addition, supernatants from SNV-infected human alveolar macrophages did not cause a significant increase in endothelial monolayer permeability.
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收藏
页码：11966 / 11971
页数：6
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