Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes of Indenoisoquinoline Derivatives

被引：16
|
作者：
Wambang, Nathalie [1 ,2 ]
Schifano-Faux, Nadege [3 ]
Martoriati, Alain [4 ]
Henry, Natacha [1 ]
Baldeyrou, Brigitte [5 ]
Bal-Mahieu, Christine [5 ]
Bousquet, Till [1 ]
Pellegrini, Sylvain [1 ]
Meignan, Samuel [5 ]
Cailliau, Katia [4 ]
Goossens, Jean-Francois [3 ]
Bodart, Jean-Francois [4 ]
Ndifon, Peter T. [2 ]
Pelinski, Lydie [1 ]
机构：
[1] Univ Lille, CNRS, UMR 8181, ENSCL,UCCS, F-59000 Lille, France
[2] Univ Yaounde I, Lab Chim Coordinat, BP 812, Yaounde, Cameroon
[3] Univ Lille, EA 7365, GRITA, F-59000 Lille, France
[4] Univ Lille, CNRS, UMR 8576, UGSF, F-59000 Lille, France
[5] Univ Lille, INSERM, U908, CPAC Cell Plast & Canc, F-59000 Lille, France
来源：
ORGANOMETALLICS | 2016年 / 35卷 / 17期
关键词：
ANTICANCER ACTIVITY; DNA-BINDING; INHIBITION; CANCER; DRUGS; CYTOTOXICITY; PERSPECTIVES; RESISTANCE; AGENTS;
D O I：
10.1021/acs.organomet.6b00440
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Novel ruthenium complexes of indenoisoquinoline derivatives were synthesized and characterized. The structure of the complex 9 was determined by single-crystal X-ray crystallography. Ruthenium complexes displayed strong DNA interactions. The cytotoxic activity of the complexes was tested against five cancer cell lines (MDA-MB-231, MCF-7, HEK-293, HT-29, and DU-145).
引用
收藏
页码：2868 / 2872
页数：5
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