Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes of Indenoisoquinoline Derivatives

被引：16

作者：

Wambang, Nathalie ^{[1
,2
]}

Schifano-Faux, Nadege ^{[3
]}

Martoriati, Alain ^{[4
]}

Henry, Natacha ^{[1
]}

Baldeyrou, Brigitte ^{[5
]}

Bal-Mahieu, Christine ^{[5
]}

Bousquet, Till ^{[1
]}

Pellegrini, Sylvain ^{[1
]}

Meignan, Samuel ^{[5
]}

Cailliau, Katia ^{[4
]}

Goossens, Jean-Francois ^{[3
]}

Bodart, Jean-Francois ^{[4
]}

Ndifon, Peter T. ^{[2
]}

Pelinski, Lydie ^{[1
]}

机构：

[1] Univ Lille, CNRS, UMR 8181, ENSCL,UCCS, F-59000 Lille, France

[2] Univ Yaounde I, Lab Chim Coordinat, BP 812, Yaounde, Cameroon

[3] Univ Lille, EA 7365, GRITA, F-59000 Lille, France

[4] Univ Lille, CNRS, UMR 8576, UGSF, F-59000 Lille, France

[5] Univ Lille, INSERM, U908, CPAC Cell Plast & Canc, F-59000 Lille, France

来源：

ORGANOMETALLICS | 2016年 / 35卷 / 17期

关键词：

ANTICANCER ACTIVITY; DNA-BINDING; INHIBITION; CANCER; DRUGS; CYTOTOXICITY; PERSPECTIVES; RESISTANCE; AGENTS;

D O I：

10.1021/acs.organomet.6b00440

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Novel ruthenium complexes of indenoisoquinoline derivatives were synthesized and characterized. The structure of the complex 9 was determined by single-crystal X-ray crystallography. Ruthenium complexes displayed strong DNA interactions. The cytotoxic activity of the complexes was tested against five cancer cell lines (MDA-MB-231, MCF-7, HEK-293, HT-29, and DU-145).

引用

页码：2868 / 2872

页数：5

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