Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

被引：50

作者：

Shushni, Muftah A. M. ^{[1
]}

Singh, Rajinder ^{[1
]}

Mentel, Renate ^{[2
]}

Lindequist, Ulrike ^{[3
]}

机构：

[1] Garyounis Univ, Fac Pharm, Dept Pharmacognosy, Benghazi, Libya

[2] Ernst Moritz Arndt Univ Greifswald, Inst Pharm, D-17487 Greifswald, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Friedrich Loffler Inst Med Microbiol, D-17487 Greifswald, Germany

来源：

MARINE DRUGS | 2011年 / 9卷 / 05期

关键词：

balticolid; antiviral; herpes simplex virus; marine fungi; CLADOSPOLIDE-B;

D O I：

10.3390/md9050844

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R, 11R), (4E, 8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC(50) value of 0.45 mu M.

引用

页码：844 / 851

页数：8

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